DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31016 and CG15864

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	170/516 - (32%)
Similarity:	262/516 - (50%)	Gaps:	72/516 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKAKNREEEYLSNPI 89
            :::|..|..|.|.|||.:.||:..|..|...|..|..:::|.:.:..:...:.|:..|.||.||:
  Fly    29 KKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPL 93

  Fly    90 DSLSLMRQMHEDWEK----VEKLLKKPVGQ-EKIALVEKMREDLPVENDLMEANQAMFRILHTYD 149
            :|..|:.::|..|.|    ..|:....:|. |...|:.||   ||..:||.:|.:.:..::..||
  Fly    94 NSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKM---LPTSSDLQQACRGIHDLMSFYD 155

  Fly   150 LEPKDVSAGWIDGV-QYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLVDQPRKY--HEV 211
            |:|::::||.:.|. |.|..::|.||..:|.||.......:|..|.:.:.....::..||  |:.
  Fly   156 LKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLIRFENKFDKYRVHKA 220

  Fly   212 MGITKADVTLLLARSLIASGNVSIATDMLMRDFMFGEAGSALTVHFLRNKPK---PSINLESWES 273
            .|       ||||::       ...||..              .|| .|||:   .|..:..::.
  Fly   221 WG-------LLLAKN-------KQLTDAF--------------YHF-ENKPEGIIASNEVIHFKE 256

  Fly   274 DESFNQLCRSSSRRQMGESKPSRLHCRYNTITTPFLKLAPFRMEELSLDPYVIFYHNVLSDAEIE 338
            :.|..|.|      .:...|||||||||||.||||.::||.:||||.||||::.:|:|:.|.||:
  Fly   257 ELSTKQNC------AVVVQKPSRLHCRYNTTTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEID 315

  Fly   339 KLKPMGKPFLERAKVFRVEKGSDEIDPSRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTR 403
            .:       |..:........|.:....|::..:::.       |.:.||   .|:.||||.:..
  Fly   316 GM-------LNSSNFGLSLTDSGQKSEVRTSKDSYIV-------DAKTLN---ERVTDMTGFSME 363

  Fly   404 SGSKMQFLKYGFGGHFVPHYDYFNSKTFSLETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQ 468
            .......:.||.|||::.|||:......:....|||||||||||..||.||||:||.:|:.|..:
  Fly   364 MSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQGDRIATVLFYLGEVDSGGATIFPMINITVTPK 428

  Fly   469 KGSALFWHNIDRKSYDYDTRTFHGACPLISGTKLVMTRWIYELDQMFLIPAVL-----PPR 524
            ||||:||:|: ..|...:.::.|.|||:|||:|.|:|:||.||.|||:.|.:.     ||:
  Fly   429 KGSAVFWYNL-HNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPCMKDSNLHPPQ 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	41/133 (31%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	61/174 (35%)
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	41/133 (31%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	34/75 (45%)
		P4Hc	313..467	CDD:214780	60/171 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461912
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900