DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31016 and PH4alphaPV

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	184/536 - (34%)
Similarity:	295/536 - (55%)	Gaps:	46/536 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLFAVSFILVLSWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKE 69
            ||.....:|:|...|:|   .:::..||...:.||:.:.:||..|:.||.||.:|:..::|.:..
  Fly    12 VLLTYQVLLLLLRQAKG---EESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITS 73

  Fly    70 FKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDL 134
            .:...:||::..|||||||::|.||:|:|:.||...:..:..|||..::..::::||.:|...|:
  Fly    74 LRLENDKARSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTHTDV 138

  Fly   135 MEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKD 199
            .||..|:.||..||.|:..::|.|:::|.||...::..|.:.||...|...:|..|:.|:  .:.
  Fly   139 EEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWI--YQS 201

  Fly   200 LLVDQPRKYHEVMGITKADVTLLLARSLIASGNVSIATDMLMRDFMFGEAGSALT-----VHFLR 259
            :::.:.......:.|:|.:|.::.|.:|:.....:.|..::         ..|||     :..|.
  Fly   202 VVLMEAFSMAAPLEISKNEVRMVYAETLLKLNQHADALKVV---------NIALTDNPHDIKLLL 257

  Fly   260 NKPK------------PSINLESWESDESFNQLCRSSSRRQMGESKPSRLHCRYNTITTPFLKLA 312
            .|.:            |.:.:::.....::...||.    |...|..|:|:|.||..|:|||.||
  Fly   258 KKSEIETMIRTGTNNAPPVKVQATGVPTAYQIGCRG----QFPPSADSKLYCLYNRTTSPFLILA 318

  Fly   313 PFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDEIDPSRSADGAWLPHQ 377
            |.:||.:.||||::.||:|||..||::|:.|..|.|:||.|::...|.:|:..:|::..||.
  Fly   319 PLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWF--- 380

  Fly   378 NIDPDDLEVLN-RIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTFSLETV--GDR 439
               ||....|. |:..||.||||.|......:|.:.||.|||:..|||:|| ||.|..|.  |||
  Fly   381 ---PDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFN-KTNSNMTAMSGDR 441

  Fly   440 IATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISGTKLVM 504
            ||||||||.:|:.|||||||.:..||..|:||.:.|:|: :.:...||:|.|.|||:|.|:|.|.
  Fly   442 IATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNL-KDNGQIDTQTLHAACPVIVGSKWVC 505

  Fly   505 TRWIYELDQMFLIPAV 520
            .:||.|.:|:|..|.:
  Fly   506 NKWIREREQIFSRPCL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	46/128 (36%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	78/177 (44%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	46/128 (36%)
		TPR_11	179..250	CDD:290150	15/81 (19%)
		TPR repeat	179..213	CDD:276809	6/35 (17%)
		TPR repeat	218..248	CDD:276809	7/38 (18%)
		P4Hc	339..510	CDD:214780	79/178 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461906
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910