DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31016 and CG15539

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	158/540 - (29%)
Similarity:	262/540 - (48%)	Gaps:	61/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVLFAVSFILVL------SWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIM 62
            ::..|:.::|||      ..|.|     .||.||:.:...|::.:..|:.:|..:|..|.:::..
  Fly     5 LISLAILYLLVLVKSHSKPKILE-----NNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDT 64

  Fly    63 LKRIVKEFKQPLEKAK-NREEEYLSNPIDSLSLMRQMHEDWEK-VEKLLKKPVG---QEKIALVE 122
            |:..       ||... :||:....:||....:.|::|.|:.. |..:.::|.|   ::.||:..
  Fly    65 LEYY-------LEMTDYDREKNLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAP 122

  Fly   123 KMREDLPVENDLMEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSY 187
            :|    |...|:.||.:.:..|..||.|...:::.|.:..:.:...:....|.|:.........:
  Fly   123 EM----PTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDF 183

  Fly   188 QIASKWLSAA-KDLLVDQPRKY-HEVMGITKADVTLL-------LARSLIASGNVSIATDMLMRD 243
            ..|.:||... |....|:..:| :..:|:...|...|       |....:|...:.:|.......
  Fly   184 IRAKEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEK 248

  Fly   244 FMFGEAGSALTVHF-LRNKPKPSINLESWESDESFNQLCRSSSRRQMGESKP-SRLHCRYNTITT 306
            .....|.|.|.::. :..:|....|    :|...:.:.|.|       |.:| ::|:|.|.|.::
  Fly   249 VSLQRALSRLKMNIRIGKEPAEKKN----KSKRVYKKCCSS-------ECRPTAKLYCLYKTTSS 302

  Fly   307 PFLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEK-GSDEIDPSRSAD 370
            .||:|||.:||.||||||::.:|:|:||.:|..::.:.|..|  |:...|.| |:...||.|:..
  Fly   303 YFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKL--ARTVTVSKDGNYTEDPDRTTK 365

  Fly   371 GAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTFSLET 435
            |.||...|      .::.|:.:..:|||..:.......|.|.||.||.:..|:|:....  .|:.
  Fly   366 GTWLVENN------ALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDA--ELDN 422

  Fly   436 VGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISGT 500
            ..|||||.:|||::|..||||:||||.|:|..:|||||.|:|:|.|. |.|.||.|.|||.:.|:
  Fly   423 FSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKG-DGDNRTAHSACPTVVGS 486

  Fly   501 KLVMTRWIYELDQMFLIPAV 520
            :.|||:||.|.:|:|..|.:
  Fly   487 RWVMTKWINEREQIFRRPCL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	31/133 (23%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	69/175 (39%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	31/133 (23%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	69/175 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461915
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900