DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31016 and CG32199

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	153/549 - (27%)
Similarity:	254/549 - (46%)	Gaps:	99/549 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKAKNREEEYLSNPIDSL 92
            |..||...|.|||.:..|...||.|..|:..|:.::|......|:........:|||:|||:::.
  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVSNPLNAF 67

  Fly    93 SLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDLMEANQAMFRILHTYDLEPKDVSA 157
            .::|::::||.|..:.:|..:..:||..:|...:..|:::||..|.:.|.||...::|..:|::.
  Fly    68 PMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLHAEDLTK 132

  Fly   158 GWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLV-DQPRK--YHEVMGITKADV 219
            |.:.|.:....::|.||..:|.:.:....:..::.|...|  |.| ..||.  |.:|:|:.:..:
  Fly   133 GVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMA--LRVHTHPRGMIYAKVLGLKRKRI 195

  Fly   220 TLLLARSLIASGNVSIATDMLMRDFMFGEAGSALTVHFLRNKPKPSINLESW------------- 271
            ....|::|:..   |:.:|                    ::||.|:...| |
  Fly   196 YKKYAKALLKE---SLNSD--------------------KSKPTPTEKSE-WNRLAKEVTREDNY 236

  Fly   272 -----------ESDESFNQ-----LCRSSSRRQMG-------ESKPSRLHCRYNTITTPFLKLAP 313
                       ..||...|     |.|..::.:.|       :|.| .|.||||..|:.||||||
  Fly   237 DNVKKLIDEYLSGDEKIFQEVAARLKRKPTKLERGCRGEWPKKSSP-ELICRYNRDTSAFLKLAP 300

  Fly   314 FRMEELSLDPYVIFYHNVLSDAEIEKLKPM---------GKPFLERAKVFRVEKGS----DEIDP 365
            .::|.||:.|.::.||:||.:.|.:.::.:         |..:::..|     ||:    |.:..
  Fly   301 LKLEFLSVQPMILLYHDVLYENEFKSMRDIAMYNGSMIDGWTYVDFDK-----KGNPKQQDRVVK 360

  Fly   366 SRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYF---- 426
            ..:..|...|.         .|: |.||:.||:||..|....:....||.||||..|.||.
  Fly   361 MIAFQGTTAPF---------TLS-INRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAK 415

  Fly   427 NSKTFSLETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFH 491
            ....|..:..||||||.|.|.:::..||.|||.||.:||..:|||||.|.|::... :.|..|.|
  Fly   416 RPPDFFADFGGDRIATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAG-EPDPLTEH 479

  Fly   492 GACPLISGTKLVMTRWIYELDQMFLIPAV 520
            ..||::.|::.::::||:|..|:|..|.:
  Fly   480 SVCPVVLGSRWIISKWIHERQQVFKKPCL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	38/128 (30%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	57/191 (30%)
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	38/128 (30%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	51/138 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461992
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910