DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31016 and CG18233

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	166/542 - (30%)
Similarity:	276/542 - (50%)	Gaps:	49/542 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSVVLFAVSFILVLSWIA---EGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIM 62
            |.:||..|...|||.|..:   ..:.:|:.|..||...:.||:.::|.::....||..|.||:..
  Fly     1 MLNVVRAAAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDN 65

  Fly    63 LKRIVKEFKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMRED 127
            |...:...|:|..|..|..|:::|||:::..|:|::::||.|::...:||:|.|::..::.:...
  Fly    66 LNIFLDALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSA 130

  Fly   128 LPVENDLMEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASK 192
            .|...|:.|..:||.||..||||:|||::.|.:...::..::...||..:....|..|.::.:..
  Fly   131 APESFDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLL 195

  Fly   193 WLSAAKDLLVDQPRKYHEVMGITKADVTLLLARSLIASGNVSIATDMLMRDFMFGEAGSAL-TVH 256
            |...|..|..|...   |:|...| ::.|....:.:|..::.::...|..:.:...|.|.| ...
  Fly   196 WFQEALKLSTDGSL---EIMNRLK-EIELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAK 256

  Fly   257 FLRNKPKPSINLESWESDES------FNQLCRSSSRRQMGESKPSRLHCRYNTITTPFLKLAPFR 315
            .:..:...|..|:.|.:|:|      .|..||...      .|.|.|.||||:.|..||||||.:
  Fly   257 LMDLEQLISSELKQWINDDSTTPPTDHNLGCRGLF------PKKSNLVCRYNSSTNAFLKLAPLK 315

  Fly   316 MEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDEI-DPSRSADGA-WLPHQN 378
            |||:|.|||::.:|.|:||.:||::|         .::..:|.|...: ||....... |:..::
  Fly   316 MEEISRDPYIVMFHEVISDKDIEEMK---------GEITEMENGWTSLGDPKEIVSRVYWIRKES 371

  Fly   379 IDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTFSLE---TVGDRI 440
                  ....||.:||.||||........:|...:|.||:|.||||::..:...::   |:||||
  Fly   372 ------SFSKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDRLKEVDVNNTLGDRI 430

  Fly   441 ATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYD---YDTRTFHGACPLISGTKL 502
            .:::||...|..||.||||.|.:||..:||:||||.|    ::|   .|.|:.|..||::.|::.
  Fly   431 GSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFN----AFDDSTPDPRSLHSVCPVLVGSRW 491

  Fly   503 VMTRWIYELDQMFLIPAVLPPR 524
            .:|:|::...|:|:.|.  .||
  Fly   492 TITKWLHYAPQLFVKPC--SPR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	43/128 (34%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	59/182 (32%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	43/128 (34%)
		ATP-synt_B	<198..278	CDD:304375	17/83 (20%)
		P4Hc	333..498	CDD:214780	60/183 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461914
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910