DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31016 and p4ha2

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	555	Identity:	162/555 - (29%)
Similarity:	272/555 - (49%)	Gaps:	59/555 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AVSFILVLSWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQ 72
            |...:.:||.::.....|.....|:.:..:|:..:|||:..|..|.....:|:    ..|:.:..
Zfish     2 AAFLVFLLSTLSFSSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKL----ETVRSWAN 62

  Fly    73 PLEK----AKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVEND 133
            .|:|    :.:..|.:|::|:::..||::::.:|.::|.|:.:......|:.:...|:..|.|.|
Zfish    63 KLDKLTRTSTSDPEGFLAHPVNAYKLMKRLNTEWSELESLVLQDPSDGFISNMSVHRQYFPDEED 127

  Fly   134 LMEANQAMFRILHTYDLEPKDVSAGWI------DGVQYGGKMSASDCFTMGTFSFMAGSYQIASK 192
            ...|.:|:.|:..||.|:.:..|.|.:      .||:|...::..|||.||..::....|..:..
Zfish   128 EKGAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVL 192

  Fly   193 WLSAAKDLLVDQPRKYHEVMGITKADVTLLLARSLIASGNVSIATDMLMR----DFMFGEAGSAL 253
            |:..:.     :.....|.....||||...|:.|:...|::..|.::..|    |.....||..|
Zfish   193 WMQQSL-----RQMDSGEEAKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNL 252

  Fly   254 TVHFLR-----------NKPKPS----INLESWE-------SDESFNQLCRSSSRRQMGESKPSR 296
            . :|.|           .:|:|:    |.|::::       ..|::..|||....: |...:.||
Zfish   253 R-YFERLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVK-MTTKRQSR 315

  Fly   297 LHCRY-NTITTPFLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGS 360
            |.||| :....|.|.|.|.:.|:....|:::.:...|||.||:|:|.:..|.|.||.|...:.|.
Zfish   316 LFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGV 380

  Fly   361 DEIDPSRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDY 425
            ..:...|.:..|||..:: ||    |:.|:.:||||:|||...:...:|...||.||.:.||:|
Zfish   381 LTVAHYRVSKSAWLEGED-DP----VIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFD- 439

  Fly   426 FNSK----TFSLETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYD 486
            |:.|    .|.....|:|:||.|.|:::|:.|||||||....:|..:||:|:||:|:.| |.:.|
Zfish   440 FSRKDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFR-SGEGD 503

  Fly   487 TRTFHGACPLISGTKLVMTRWIYELDQMFLIPAVL 521
            .||.|.|||::.|:|.|..:||:|..|.|..|..|
Zfish   504 YRTRHAACPVLVGSKWVSNKWIHERGQEFRRPCGL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	32/132 (24%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	71/178 (40%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	32/132 (24%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	72/179 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920