DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31016 and P4ha3

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	145/517 - (28%)
Similarity:	234/517 - (45%)	Gaps:	87/517 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSY----------ATELNEKIIMLKRIVKEFKQP 73
            |.|..|..:.:.||..   .|..:|.|:..|..|          .|...:|::.|.   ::.|.|
  Rat    24 AAGREDTFSALTSVAR---ALAPERRLLGTLRRYLRGEEARLRDLTRFYDKVLSLH---EDLKIP 82

  Fly    74 LEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALV----EKMREDLPVENDL 134
                       :.||:.:.:|::::..||..|...|:   ..|.|..:    ||:.:|||...||
  Rat    83 -----------VVNPLLAFTLIKRLQSDWRNVVHSLE---ATENIRALKDGYEKVEQDLPAFEDL 133

  Fly   135 MEANQAMFRILHTYDLEPKDVSAGWIDGVQ-------YGGK----MSASDCFTMGTFSFMAGSYQ 188
            ..|.:|:.|:...|.|..|.::.|....|.       |..:    ::|.|||.:|..::..|.|.
  Rat   134 EGAARALMRLQDVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYY 198

  Fly   189 IASKWLSAAKDLLVDQPRKYHEVMGITKA---DVTLLLARSLIASGNVSIATDMLMRDF------ 244
            .|..||..|..|.   .|.|.|.....:|   |....||.:....||||.|.. |.|:|
  Rat   199 HAIPWLEEAVSLF---RRSYGEWKTEDEASLEDALDYLAFACYQVGNVSCALS-LSREFLVYSPD 259

  Fly   245 -------------MFGEAGSALTVHFLRNKPKPSINLESWESDESFNQLCRSSSRRQMGESKPSR 296
                         :..|.|..:.......:|    |:...::.:::..||::...:......||
  Rat   260 NKRMARNVLKYERLLAENGHLMAAETAIQRP----NVPHLQTRDTYEGLCQTLGSQPTHYQIPS- 319

  Fly   297 LHCRYNTITTPFLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSD 361
            |:|.|.|.::|:|.|.|.|.|.:.|.|.|..||:.:||.|.:|::.:.:|:|:|:.|...|| ..
  Rat   320 LYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVASGEK-QL 383

  Fly   362 EIDPSRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRS--GSKMQFLKYGFGGHFVPHYD 424
            ::: .|.:..||| ...:||    ||..:.|||..:|||:.:.  ...:|.:.||.|||:.||:|
  Rat   384 QVE-YRISKSAWL-KDTVDP----VLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHFD 442

  Fly   425 YFNSKTFSLETV--GDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYD 484
            :..|.:..|..:  |:|:||::.||::|:.||||.|...|.:||..|.....:.::||.|.|
  Rat   443 HATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGNFSVPVVKWPTSGYTSMDRNSED 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	35/142 (25%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	55/156 (35%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	18/90 (20%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	46/128 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750