DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31016 and P4ha2

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	159/550 - (28%)
Similarity:	270/550 - (49%)	Gaps:	61/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VVLFAVSFILVLSWIAEGYRDRQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVK 68
            |::..:|:..||||:      :..:..|:....||:..:::|:..|..|......|:..:|....
  Rat     5 VLVLLMSWFGVLSWV------QAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWAS 63

  Fly    69 EFKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVEND 133
            :.:....|:....|.||::|:::..|:::::.||..:..|:.:......:|.:...|:..|.:.|
  Rat    64 KMEALTSKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAAAGFVANLSVQRQFFPTDED 128

  Fly   134 LMEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWL---- 194
            ...|.:|:.|:..||.|:|..:|.|.:.|.:|...:|..|||.||..::..|.|.....|:
  Rat   129 ESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVL 193

  Fly   195 ---------SAAKDLLVD-------QPRKYHEVMGITKADVTLLLARSLIASGNVSIATDMLMRD 243
                     :..|.|::|       |....|..:.:|:..::|..:... |.||:.....:|..
  Rat   194 KQLDAGEEATVTKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHER-AGGNLRYFERLLEE- 256

  Fly   244 FMFGEAGSALTVHFLRNKPKPSI----NLESWESD-----ESFNQLCRSSSRRQMGESKPSRLHC 299
                |.|.:|:     |:....:    ||.....|     :.:..|||....: |...:..||.|
  Rat   257 ----ERGKSLS-----NQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIK-MTPRRQKRLFC 311

  Fly   300 RY---NTITTPFLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSD 361
            ||   |.:  |.|.:|||:.|:....|:::.|::|:||.|||::|.:.||.|.||.|...:.|..
  Rat   312 RYHHGNRV--PQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVL 374

  Fly   362 EIDPSRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYF 426
            .:...|.:..:||     :.||..|:.|:.||::.:|||..::...:|...||.||.:.||:|:.
  Rat   375 TVASYRVSKSSWL-----EEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFS 434

  Fly   427 NS---KTFSLETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTR 488
            .|   ..|.....|:|:||.|.|:::|:.|||||||.|..|:..:||:|:||:|:.| |.:.|.|
  Rat   435 RSDERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLR-SGEGDYR 498

  Fly   489 TFHGACPLISGTKLVMTRWIYELDQMFLIP 518
            |.|.|||::.|.|.|..:|.:|..|.||.|
  Rat   499 TRHAACPVLVGCKWVSNKWFHERGQEFLRP 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	30/128 (23%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	69/177 (39%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	15/76 (20%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	70/178 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920