DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31016 and P4ha1

DIOPT Version :9

Sequence 1:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001303300.1	Gene:	P4ha1 / 18451	MGIID:	97463	Length:	534	Species:	Mus musculus

Alignment Length:	523	Identity:	151/523 - (28%)
Similarity:	258/523 - (49%)	Gaps:	42/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 YVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKAKNREEEYLSNPIDSL 92
            :..|:.:..||:..:::|:..|..|.....:|:..:|:..::..:....|....|.::.:|:::.
Mouse    21 FFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly    93 SLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDLMEANQAMFRILHTYDLEPKDVSA 157
            .||::::.:|.::|.|:.|.:....|:.:...|:..|.:.|.:.|.:|:||:..||:|:...:|.
Mouse    86 KLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISK 150

  Fly   158 GWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLVDQPRKYHEVMGITKA----- 217
            |.:.|||:...::|.|||.:|..::....|.....|:..|...|.:     .|:..:.|.
Mouse   151 GNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALTQLEE-----GELSTVDKVSVLDY 210

  Fly   218 -----------DVTLLLARSLI--------ASGNVSIATDMLMRDFMFGEAGSALTVHFLRNKPK 263
                       |..|||.:.|:        |:||:.....::.::....::.|...........|
Mouse   211 LSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTAPKK 275

  Fly   264 PSINLESWESDESFNQLCRSSSRRQMGESKPSRLHCRYNT-ITTPFLKLAPFRMEELSLDPYVIF 327
            ..|.::.....:.:..|||....: |...:..||.|||:. ...|...|||.:.|:....|.:|.
Mouse   276 KGIAVDYLPERQKYEMLCRGEGIK-MTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIR 339

  Fly   328 YHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDEIDPSRSADGAWLPHQNIDPDDLEVLNRIGR 392
            :|:::||||||.:|.:.||.|.||.|...|.|.......|.:..|||.... ||    |::||..
Mouse   340 FHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYE-DP----VVSRINM 399

  Fly   393 RIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNS---KTFSLETVGDRIATVLFYLNNVDHGG 454
            ||:|:|||:..:..::|...||.||.:.||:|:...   ..|.....|:||||.|||:::|..||
Mouse   400 RIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGG 464

  Fly   455 ATVFPKLNLAVPTQKGSALFWHNIDRKSY-DYDTRTFHGACPLISGTKLVMTRWIYELDQMFLIP 518
            |||||::..:|..:||:|:||:|:..... ||.||  |.|||::.|.|.|..:|::|..|.|..|
Mouse   465 ATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTR--HAACPVLVGNKWVSNKWLHERGQEFRRP 527

  Fly   519 AVL 521
            ..|
Mouse   528 CTL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	30/128 (23%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	73/178 (41%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	30/128 (23%)
		TPR	205..238		5/32 (16%)
		P4Hc	345..518	CDD:214780	74/179 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920