DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaSG1 and P4HTM

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	475	Identity:	108/475 - (22%)
Similarity:	154/475 - (32%)	Gaps:	198/475 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LGN-----LKLAYKLNNEILDKKPDH-------EEALKNKILYEG---------QLARERSFAPR 272
            |||     |.:.|...:|..|..|.|       |..|......||         ||..:|....|
Human    72 LGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIR 136

  Fly   273 K------QVELPQIAEKEQKESYKLYTQVCRGELHQS-----------PREQRNLRCWLYHQGVP 320
            .      ..|:|.....|:          ||..:|.:           |.|:       |.:.:.
Human   137 TLSLKPLLFEIPGFLTDEE----------CRLIIHLAQMKGLQRSQILPTEE-------YEEAMS 184

  Fly   321 YYRLSP---FKIEQLNVDPYVAYVHEVL--------WDSEIDTIME---------HGKG------ 359
            ..::|.   |::...|.|.:: .:.|||        |....::|.|         .|.|
Human   185 TMQVSQLDLFRLLDQNRDGHL-QLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQE 248

  Fly   360 --NMER---SKVGQSENSTTSE-VRISRNTWLWY--DANPWLSKIKQRLEDVTGLS---TESAEP 413
              ||:.   .|..:|..:.:|| ||.|.:|||:.  .|:..:..|:||:..:|.||   .|.:||
Human   249 FSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEP 313

  Fly   414 LQLVNYGIGGQYEPHFD--------------FVEDDGQ--------------------------- 437
            ||:|.||.||.|..|.|              .|.::..
Human   314 LQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNWGLPSILRPGTPMTQ 378

  Fly   438 --------------------SVFSWKGNRL------------LTALFYLNDVALGGATAFPF--- 467
                                .|..|:..:|            :|.|||||:|..||.|.||.
Human   379 AQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADN 443

  Fly   468 --------------LR----------LAVPPVKGSLLIWYNLHSSTH-----KDFRTKHAGCPVL 503
                          ||          |.|.|.:|:.:.|||......     .|..:.|.||.|.
Human   444 RTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVT 508

  Fly   504 QGSKWICNEWFHVGAQEFRR 523
            :|:|||.|.|.:|.....|:
Human   509 RGTKWIANNWINVDPSRARQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	72/298 (24%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111		6/21 (29%)
		EF-hand_7	192..252	CDD:290234	11/60 (18%)
		EFh	194..252	CDD:238008	11/58 (19%)
		P4Hc	246..519	CDD:214780	67/272 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740