Protein Alignment PH4alphaSG1 and P4HA1

DIOPT Version :9

• Sequence 1: NP_733376.1
• Gene: PH4alphaSG1 / 326112
• FlyBaseID: FBgn0051014
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 190/541 - (35%)
• Similarity: 298/541 - (55%)
• Gaps: 56/541 - (10%)

  Fly    20 YYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDE-QQNDRGDLEEYFGNPINAF 83
            ::::|.::..|:..|..:|....:|::..:.:.|.:|::.:::|. ......|.|.:.|:|:|||
Human    21 FFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAF 85

  Fly    84 ITIKRLVHDWKFNVFDPVFDSSNFET-YKNNLSD------SLEKINFKGPTQEDLHGATRALLRL 141
            ..:|||..:|           |..|. ...::||      ::::..|  |..||..||.:|||||
Human    86 KLMKRLNTEW-----------SELENLVLKDMSDGFISNLTIQRQYF--PNDEDQVGAAKALLRL 137

  Fly   142 QNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKRLHGKPL 206
            |:.|.|:||.::.|.| ||.|:.  :.|:|.|||||||......:|.:...|:.:|.::|..
Human   138 QDTYNLDTDTISKGNL-PGVKHK--SFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDE--- 196

  Fly   207 GFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALKNKILYEGQLARERSF-- 269
            |.|| .:..|.:|::||.|....|:|..|..|..::|:..|:|:.|..|...:|..:|:|:..
Human   197 GEIS-TIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNK 260

  Fly   270 -----------APRKQ-VELPQIAEKEQKESYKLYTQVCRGE-LHQSPREQRNLRCWLYHQG--V 319
                       .|:|: |.:..:.|:::      |..:|||| :..:||.|:.|.| .||.|  .
Human   261 SASDDQSDQKTTPKKKGVAVDYLPERQK------YEMLCRGEGIKMTPRRQKKLFC-RYHDGNRN 318

  Fly   320 PYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENS--TTSEVRISRN 382
            |.:.|:|.|.|.....|.:...|:::.|:||:.:.:..|..:.|:.|...|..  ||::.|:|::
Human   319 PKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKS 383

  Fly   383 TWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFS--WKGN 445
            .||....||.:|:|..|::|:|||...:||.||:.|||:||||||||||...|....|.  ..||
Human   384 AWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGN 448

  Fly   446 RLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGSKWIC 510
            |:.|.|||::||:.||||.||.:..:|.|.||:.:.||||.:|...|:.|:||.||||.|:||:.
Human   449 RIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVS 513

  Fly   511 NEWFHVGAQEFRRPCGLSSDE 531
            |:|.|...|||||||.||..|
Human   514 NKWLHERGQEFRRPCTLSELE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	40/141 (28%)
		P4Hc	347..515	CDD:214780	78/171 (46%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	23/97 (24%)
		TPR	205..238		11/32 (34%)
		P4Hc	345..518	CDD:214780	78/172 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820