DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and PH4alphaPV

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	165/539 - (30%)
Similarity:	264/539 - (48%)	Gaps:	55/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IILSLLCVFPVNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQQND-- 68
            ::|.||........:.::::.:.:|||:||.:::..::|....:::.:.::|.:..: ..:||
  Fly    18 VLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSL-RLENDKA 81

  Fly    69 RGDLEEYFGNPINAFITIKRLVHD---WKFNVFDPVFDSSNFETYKNNLSDSLEKINFKGPTQED 130
            |...|||..||:|:|..|:|:..|   |:..:.|||..|.         .:.::::....||..|
  Fly    82 RSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQ---------VERIQELREHMPTHTD 137

  Fly   131 LHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEW-- 193
            :..|..||.|:|:.|.|....::.|.|:..:.|   .||:..|.:.:|:.|.:.|.|...:.|
  Fly   138 VEEAVTALDRIQSTYGLKVPEISHGFLNGKQYN---VSLTVLDTYAMGQILFDQKNYLAAASWIY 199

  Fly   194 ----LLEARKRLHGKPLGFISPNVSDVEILEHLSSAFNGLGNLKL-----AYKLNNEILDKKPDH 249
                |:||...  ..||. ||.|...:...|.|         |||     |.|:.|..|...|..
  Fly   200 QSVVLMEAFSM--AAPLE-ISKNEVRMVYAETL---------LKLNQHADALKVVNIALTDNPHD 252

  Fly   250 EEALKNKILYEGQLARERSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWL 314
            .:.|..|...|..:....:.||..:|:...:.        ..|...|||:.  .|.....|.| |
  Fly   253 IKLLLKKSEIETMIRTGTNNAPPVKVQATGVP--------TAYQIGCRGQF--PPSADSKLYC-L 306

  Fly   315 YHQGV-PYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENSTTSEV- 377
            |::.. |:..|:|.|:|.:.:|||:...|:||...||..:.......::|:.|.|:.:.....|
  Fly   307 YNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVK 371

  Fly   378 -RISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFS 441
             |.|:..|.....||...::..|:.|:||.:...:|.|||:|||:||.|:.|:||......::.:
  Fly   372 TRTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTA 436

  Fly   442 WKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGS 506
            ..|:|:.|.||||.||..||||.||.:|.||.|.:||:::||||..:...|.:|.||.|||:.||
  Fly   437 MSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGS 501

  Fly   507 KWICNEWFHVGAQEFRRPC 525
            ||:||:|.....|.|.|||
  Fly   502 KWVCNKWIREREQIFSRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	36/138 (26%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	67/169 (40%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	36/138 (26%)
		TPR_11	179..250	CDD:290150	22/82 (27%)
		TPR repeat	179..213	CDD:276809	8/35 (23%)
		TPR repeat	218..248	CDD:276809	10/38 (26%)
		P4Hc	339..510	CDD:214780	67/170 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461947
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900