Protein Alignment PH4alphaSG1 and PH4alphaPV

DIOPT Version :10

• Sequence 1: NP_733376.1
• Gene: PH4alphaSG1 / 326112
• FlyBaseID: FBgn0051014
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_733395.1
• Gene: PH4alphaPV / 43640
• FlyBaseID: FBgn0051015
• Length: 525
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 165/539 - (30%)
• Similarity: 264/539 - (48%)
• Gaps: 55/539 - (10%)

  Fly     6 IILSLLCVFPVNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQQND-- 68
            ::|.||........:.::::.:.:|||:||.:::..::|....:::.:.::|.:..: ..:||
  Fly    18 VLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSL-RLENDKA 81

  Fly    69 RGDLEEYFGNPINAFITIKRLVHD---WKFNVFDPVFDSSNFETYKNNLSDSLEKINFKGPTQED 130
            |...|||..||:|:|..|:|:..|   |:..:.|||..|.         .:.::::....||..|
  Fly    82 RSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQ---------VERIQELREHMPTHTD 137

  Fly   131 LHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEW-- 193
            :..|..||.|:|:.|.|....::.|.|:..:.|   .||:..|.:.:|:.|.:.|.|...:.|
  Fly   138 VEEAVTALDRIQSTYGLKVPEISHGFLNGKQYN---VSLTVLDTYAMGQILFDQKNYLAAASWIY 199

  Fly   194 ----LLEARKRLHGKPLGFISPNVSDVEILEHLSSAFNGLGNLKL-----AYKLNNEILDKKPDH 249
                |:||...  ..||. ||.|...:...|.|         |||     |.|:.|..|...|..
  Fly   200 QSVVLMEAFSM--AAPLE-ISKNEVRMVYAETL---------LKLNQHADALKVVNIALTDNPHD 252

  Fly   250 EEALKNKILYEGQLARERSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWL 314
            .:.|..|...|..:....:.||..:|:...:.        ..|...|||:.  .|.....|.| |
  Fly   253 IKLLLKKSEIETMIRTGTNNAPPVKVQATGVP--------TAYQIGCRGQF--PPSADSKLYC-L 306

  Fly   315 YHQGV-PYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENSTTSEV- 377
            |::.. |:..|:|.|:|.:.:|||:...|:||...||..:.......::|:.|.|:.:.....|
  Fly   307 YNRTTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVK 371

  Fly   378 -RISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFS 441
             |.|:..|.....||...::..|:.|:||.:...:|.|||:|||:||.|:.|:||......::.:
  Fly   372 TRTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTA 436

  Fly   442 WKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGS 506
            ..|:|:.|.||||.||..||||.||.:|.||.|.:||:::||||..:...|.:|.||.|||:.||
  Fly   437 MSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGS 501

  Fly   507 KWICNEWFHVGAQEFRRPC 525
            ||:||:|.....|.|.|||
  Fly   502 KWVCNKWIREREQIFSRPC 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..159	CDD:462433	37/140 (26%)
		P4Hc	347..515	CDD:214780	67/169 (40%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..166	CDD:462433	37/140 (26%)
		NrfG	179..>256	CDD:443378	23/88 (26%)
		TPR repeat	179..213	CDD:276809	8/35 (23%)
		TPR repeat	218..248	CDD:276809	10/38 (26%)
		P4Hc	339..510	CDD:214780	67/170 (39%)