DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and PH4alphaNE1

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	198/556 - (35%)
Similarity:	296/556 - (53%)	Gaps:	71/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILSLLCVFPVNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQQN-DRG 70
            ::.||....:..||:|:|:.||.||..|.::..:....:...|...:.|:..|..|:::.. ...
  Fly    10 LIFLLAQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEHTMAAS 74

  Fly    71 DLEEYFGNPINAFITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSDSLEKINFKG--------PT 127
            |.|.|..||:|.:..:|||..||..              .:..:....|::||..        |:
  Fly    75 DTENYLTNPVNVYRLMKRLHTDWSL--------------MEGRVQLMAEEMNFNATREYGLSYPS 125

  Fly   128 QEDLHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSE 192
            |||:.||..||:|||:.|:|:...:|.|:|: |.|  .|:.:|..||||||:.|.|:::|:....
  Fly   126 QEDVEGAALALVRLQSTYKLDVAQVAQGILN-GVK--YGSDMSWQDCFELGQQLFEMEDYNNTKV 187

  Fly   193 WLLEARKRL---------HGKPLGFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPD 248
            ||.|:.:||         |..|..  .|:...:..:|..:.:...||:...|::|:..:|...|
  Fly   188 WLRESMERLRRQTSHAPSHLAPTS--GPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQFDP- 249

  Fly   249 HEEALKNKILYEGQLARERSFAPRKQVE---LPQIAEKEQKESYKL------YTQVCRGELHQSP 304
              :.::|..|      .::..||.:.::   ||     :..:||.|      |.:|||||:|  |
  Fly   250 --KRIRNWHL------GDKGTAPPEDIDDVYLP-----KHSDSYSLSQEFAKYEKVCRGEVH--P 299

  Fly   305 REQRNLRCWLYHQGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKV--- 366
            ..::.|||.......||..|:|.|:|:.::|||||..|::|...:|..:.|.....|.||.|
  Fly   300 IVRQELRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRSTVNPL 364

  Fly   367 --GQSENSTTSEVRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHF 429
              ||.:.|.   .|:|:|.||.|:::|.:..:.:.|:|.|||.|...|.||:.|||:||.||||:
  Fly   365 PGGQLKKSA---FRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEPHW 426

  Fly   430 DFVEDDGQSVFSWKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFR 494
            ||..|..... :.:|||:.||:|||::|..|||||||||.:||.|..|::|.|||||.|..||:|
  Fly   427 DFFRDPNHYP-AEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYR 490

  Fly   495 TKHAGCPVLQGSKWICNEWFHVGAQEFRRPCGLSSD 530
            |||||||||:|||||.|.|.|...|.|.|||.:..|
  Fly   491 TKHAGCPVLKGSKWIGNVWIHEVTQTFARPCDVFRD 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	39/142 (27%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	85/172 (49%)
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	39/142 (27%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	85/173 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461962
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900