DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	197/551 - (35%)
Similarity:	298/551 - (54%)	Gaps:	47/551 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSIILSLLCVFPVNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQI---DEQ 65
            :.|...::.|...||::||::..::.|..||..::.....|:|..|::.:..:|:::||   .|.
  Fly     9 IGIFQLIIWVGVANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEW 73

  Fly    66 QNDRGDLEEYFGNPINAFITIKRLVHDWKFNVFDPVFDSS---NFETYKNNLSDSLEKINFKGPT 127
            ...:..|::|.|:|::||..|||||.||...:|:|:..::   .|..:...||..|..     |.
  Fly    74 ATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGY-----PD 133

  Fly   128 QEDLHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSE 192
            |.:|.||.:.|.|||.:|.|.|..||.|::  |..| .|:.|...:|:|:|..|.::.||....|
  Fly   134 QSELQGAIKGLARLQKVYNLATSDLADGII--GGLN-YGSDLRWRECYEIGVQLFDLGEYQRSLE 195

  Fly   193 WLLEARKRLHGKPL------GFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEE 251
            ||..|...|...|.      .::|      :|.|:.|.|...|||.|.|.:|.::||:.:|.|..
  Fly   196 WLQVAFILLRNSPREEKDADHYLS------DIREYASMANFELGNPKKAARLLSQILESQPTHSA 254

  Fly   252 ALKNKILYEGQLARERSFAPRKQVELPQIAEKEQKES-YKLYTQVCRGELHQSPREQRNLRCWLY 315
            ....|.|        .|..|.|.|:       |.|.| :..||::|:|......|....|||:|.
  Fly   255 QQTQKYL--------ESRVPGKNVQ-------ETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLD 304

  Fly   316 HQGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHG-KGNMERSKV-GQSENSTTSEVR 378
            .:...|:.|:|.::|.:::||.:...|.:|...:|.:|.|.. |..|.||.| |.....|..::|
  Fly   305 GKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEGTVRDLR 369

  Fly   379 ISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFSWK 443
            :|:.|||.| .:|.::.:.:.::.|:|.....||.:|:.|||:|||||||.|:.|.:....|  :
  Fly   370 VSQQTWLDY-KSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNF--E 431

  Fly   444 GNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGSKW 508
            |:|:.|::|||:||..||.|.|..|.:.:|||||:|::|:|||.|.|.|.||.||||||:.|||.
  Fly   432 GDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKR 496

  Fly   509 ICNEWFHVGAQEFRRPCGLSSDEGKFLHLKD 539
            |.|.|.|.|.|||||||.|:||..|.|..:|
  Fly   497 IGNIWMHSGYQEFRRPCNLTSDSYKSLAYRD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	44/139 (32%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	75/169 (44%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	44/139 (32%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	75/170 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461952
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	1	0.950	-	0	Normalized mean entropy	S4458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.850