DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaSG1 and CG18749

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	158/541 - (29%)
Similarity:	235/541 - (43%)	Gaps:	128/541 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKR-FLDQIDEQQNDRGDLEEYFGNPINAF 83
            |.::..||.:||:||..:|:....|::..:.:...::| .:|...|....:.|.|.|.|||:|:|
  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSF 96

  Fly    84 ITIKRLVHDWKFNVFDPVFDSSNFETY----KNNLSDSLEKINFKG---PTQEDLHGATRALLRL 141
            ..|.||...|:           .:..|    :||....:|......   ||..||..|.|.:..|
  Fly    97 RLIHRLHTSWR-----------KWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDL 150

  Fly   142 QNMYQLNTDHLASGVL----HPGEKNALGTSLSASDCFELGK--------NLCE----------- 183
            ...|.|..:.||:|.|    .|      ||.|:|.||..||:        :|.|
  Fly   151 MYFYDLKPEELAAGNLAGYSQP------GTGLTAYDCLALGEFGVQNQKDDLAEAWYNLSLTRFD 209

  Fly   184 --IKEYSYGSEWLLEARKRLHGKPLGFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKK 246
              |::|.....|.|            .::.|....|..:|                     .:.|
  Fly   210 NIIEKYQVHKAWAL------------LLAKNKQLTEAFQH---------------------FENK 241

  Fly   247 PDHEEALKNKILYEGQLARERSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLR 311
            |:...|....|.:||.||.                           ||.|...: |.|  .:.|.
  Fly   242 PEGIVASNEVIHFEGVLAT---------------------------TQNCTAVV-QKP--SKKLH 276

  Fly   312 CWLYHQGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSE--NSTT 374
            |.......|:.|::|.|:|:|.:|||:...|:|::|:|||       |.:..|..|.||  :...
  Fly   277 CRYNTSTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEID-------GMLNSSDFGLSESVSGLK 334

  Fly   375 SEVRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSV 439
            ||||.|:::.: .||    ..:.:|:.|:||||.|.::|..|:|||:||.:..|.||.|....:.
  Fly   335 SEVRTSKDSHI-VDA----KTLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTR 394

  Fly   440 FSWKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQ 504
            .. :|:|:.|.||||.:|..||||.||.|.:.|.|.|||.:.|||||:|...:.:|.|..|||:.
  Fly   395 LK-QGDRIATVLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVIS 458

  Fly   505 GSKWICNEWFHVGAQEFRRPC 525
            |||::..:|.:...|.|..||
  Fly   459 GSKYVLTKWINELPQMFVTPC 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	39/141 (28%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	69/169 (41%)
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	39/141 (28%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	67/166 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461965
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890