DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and P4ha3

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	159/507 - (31%)
Similarity:	241/507 - (47%)	Gaps:	45/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQQNDRGDLEEYFGNPINAF 83
            |.:||::.:.|.|..|..::.....||...:....:|.||.|::.....   ||:....||:.||
  Rat    29 DTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFYDKVLSLHE---DLKIPVVNPLLAF 90

  Fly    84 ITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSDSLEKINFKGPTQEDLHGATRALLRLQNMYQLN 148
            ..||||..||: ||...:..:.|...    |.|..||:....|..|||.||.|||:|||::|.||
  Rat    91 TLIKRLQSDWR-NVVHSLEATENIRA----LKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLN 150

  Fly   149 TDHLASGVLHPGEKNALGT------------SLSASDCFELGKNLCEIKEYSYGSEWLLEA---R 198
            ...||.||.    :...|:            ||:|.|||::||...:..:|.:...||.||   .
  Rat   151 VKGLAQGVF----QRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWLEEAVSLF 211

  Fly   199 KRLHGKPLGFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALKNKILYEGQL 263
            :|.:|:.......::.|.  |::|:.|...:||:..|..|:.|.|...||::...:|.:.||..|
  Rat   212 RRSYGEWKTEDEASLEDA--LDYLAFACYQVGNVSCALSLSREFLVYSPDNKRMARNVLKYERLL 274

  Fly   264 ARE-RSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQR--NLRCWLYHQGVPYYRLS 325
            |.. ...|....::.|.:...:.:::|:...|.    |...|...:  :|.|.......||..|.
  Rat   275 AENGHLMAAETAIQRPNVPHLQTRDTYEGLCQT----LGSQPTHYQIPSLYCSYETNSSPYLLLQ 335

  Fly   326 PFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENSTTSEVRISRNTWLWYDAN 390
            |.:.|.:::.|.||..|:.:.|.|...|.|..:..::||.|...|.....|.|||::.||....:
  Rat   336 PARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVD 400

  Fly   391 PWLSKIKQRLEDVTGLSTES--AEPLQLVNYGIGGQYEPHFDFVEDDGQSVFSWK-GNRLLTALF 452
            |.|..:.:|:..:|||..:.  ||.||:|||||||.||||||........::..| |||:.|.:.
  Rat   401 PVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYKMKSGNRVATLMI 465

  Fly   453 YLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQ 504
            ||:.|..||||||.:...:||.||      :.....|..|..::....|:|:
  Rat   466 YLSSVEAGGATAFIYGNFSVPVVK------WPTSGYTSMDRNSEDPAAPILK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	47/133 (35%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	59/161 (37%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	23/77 (30%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	49/121 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343150
Domainoid	1	1.000	63	1.000	Domainoid score	I9991
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850