DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and P4ha2

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	186/543 - (34%)
Similarity:	295/543 - (54%)	Gaps:	33/543 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RLSIILSLLCVFP----VNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQID 63
            :|.:::.|:..|.    |..:::::|..:..|:..|..:|:...||:...:.:...:|.:..:::
  Rat     2 KLQVLVLLMSWFGVLSWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKME 66

  Fly    64 E-QQNDRGDLEEYFGNPINAFITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSDSLEKINFKGPT 127
            . ......|.|.|..:|:||:..:|||..||. .:.|.|...: ...:..||  |:::..|  ||
  Rat    67 ALTSKSAADPEGYLAHPVNAYKLVKRLNTDWP-ALGDLVLQDA-AAGFVANL--SVQRQFF--PT 125

  Fly   128 QEDLHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSE 192
            .||..||.|||:|||:.|:|:.|.::.|.| ||.|  ....||..|||.:|::.....:|.:...
  Rat   126 DEDESGAARALMRLQDTYKLDPDMISRGEL-PGTK--YQAMLSVDDCFGMGRSAYNEGDYYHTVL 187

  Fly   193 WLLEARKRLHGKPLGFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALKNKI 257
            |:.:..|:|.......::.::    :|::||.|...||:|..|.:|...:|...|.||.|..|..
  Rat   188 WMEQVLKQLDAGEEATVTKSL----VLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLR 248

  Fly   258 LYEGQLARERSFAPRKQVELPQIAEK---EQKESY----KLYTQVCRGE-LHQSPREQRNLRCWL 314
            .:|..|..||..:...|.:....:::   |:...|    .:|..:|||| :..:||.|:.|.| .
  Rat   249 YFERLLEEERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFC-R 312

  Fly   315 YHQG--VPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENS--TTS 375
            ||.|  ||...::|||.|.....|::...::|:.|.||:.|.|..|..:.|:.|...:..  |.:
  Rat   313 YHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVA 377

  Fly   376 EVRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVF 440
            ..|:|:::||..|.:|.::::.:|::.:|||:.::||.||:.|||:||||||||||...|.:..|
  Rat   378 SYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDAF 442

  Fly   441 S--WKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVL 503
            .  ..|||:.|.|.|::||..||||.||.|..|:.|.||:.:.||||..|...|:||:||.||||
  Rat   443 KRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVL 507

  Fly   504 QGSKWICNEWFHVGAQEFRRPCG 526
            .|.||:.|:|||...|||.||||
  Rat   508 VGCKWVSNKWFHERGQEFLRPCG 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	40/134 (30%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	76/171 (44%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	19/77 (25%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	76/172 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820