DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and CG31013

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	166/541 - (30%)
Similarity:	251/541 - (46%)	Gaps:	70/541 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLLCVFPVNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQI-DEQQNDRGD 71
            |||:.:.|              ||::|..:::..:.|....:|:.|.::..|..| .|.:..|.:
  Fly    30 LSLVTMVP--------------LLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRN 80

  Fly    72 LEEYFGNPINAFITIKRLVHDW----KFNVFDPV--FDSSNFETYKNNLSDSLEKINFKGPTQED 130
            ...|..||:|.|..|:||..||    |: :..||  :....|.::|:.|           ||:.|
  Fly    81 AISYLSNPLNGFSIIRRLHQDWINWRKY-MEQPVGIWQLKAFYSWKDEL-----------PTERD 133

  Fly   131 LHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLL 195
            |..|...:.|:|:.|.|......:|.::..:.|   .|:|.:|...:|..|......|...:||.
  Fly   134 LWDACEGIARIQSTYDLKVGDFINGNINGKQYN---DSMSTADILSVGAYLFMKNRPSDAIQWLQ 195

  Fly   196 EARKRLHGKPLGFISPN---VSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEAL---- 253
            |..:||..:.|  |.|.   :.:|:.|..|:.|.....|...|..|.:..|..:|.....|
  Fly   196 EVPQRLQEELL--IQPRHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARVLRLWK 258

  Fly   254 KNKILYEGQLARERSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWLYHQG 318
            |.....|.|  .::|....|:..:| ||     .::||   .|.|.|..|.|    |.|:.....
  Fly   259 KTTDFIENQ--PDQSPTENKKRNVP-IA-----NAFKL---SCNGPLESSTR----LHCFYNFTT 308

  Fly   319 VPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENST--TSEVRISR 381
            .|:.||:|.|.||:.:||||...||||...||..::.....||:.:|: ..|.:.  .:..|.::
  Fly   309 TPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKI-HKERAVPKKNRGRTAK 372

  Fly   382 NTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVE------DDGQSVF 440
            ..||..::|....:|.:|:.|:||.....:|..|::||||||.|..|.|:.:      .|.:|.:
  Fly   373 GFWLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRY 437

  Fly   441 SWK-GNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQ 504
            |.. |:|:.|.||||.||..||||.|..:...|.|..|:.:.||||.:..:.|.||:||.|||:.
  Fly   438 SIDLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIV 502

  Fly   505 GSKWICNEWFHVGAQEFRRPC 525
            ||||:..||.....|.|.|||
  Fly   503 GSKWVMTEWIREKRQIFIRPC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	36/140 (26%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	64/176 (36%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	39/154 (25%)
		TPR_11	178..248	CDD:290150	19/71 (27%)
		TPR repeat	211..246	CDD:276809	8/34 (24%)
		P4Hc	336..513	CDD:214780	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461967
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900