DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG1 and CG31524

DIOPT Version :9

Sequence 1:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	162/527 - (30%)
Similarity:	260/527 - (49%)	Gaps:	43/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQQNDRGDLEEYFGNPINAFITIK 87
            ::..::.||::|..:|.|.:.|.|:...:...::..:.|:.||. |:...|:.| :..|.:..|:
  Fly    31 SVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQMREQL-DKSKKEQSF-DLFNRYSFIR 93

  Fly    88 RLVHD---WKFNVFDPVF-DSSNFETYKNNLSDSLEKINFKGPTQEDLHGATRALLRLQNMYQLN 148
            .:..|   ||..:..||. |..|::          :..|.:.|.:.||..|:.|:.|:|..|.:.
  Fly    94 HMQADWLMWKQYLDKPVIRDELNYK----------QMDNLRMPQELDLFDASEAIRRMQATYAML 148

  Fly   149 TDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKRLHGKPLGFISPNV 213
            ::.:|.|.|...:..   :.||..||..:|::|.....::...:|:|...|....|     .|.
  Fly   149 SNDIAEGFLDGVQYT---SKLSPIDCLAMGRHLMNQSRWTIAEQWILAGIKAQDRK-----GPQ- 204

  Fly   214 SDVEILEHLSSA--FNGLGNLKLAYKLNNEILDKKPDHEEALKN-----KILYEGQLARER--SF 269
            :::.:|...:.|  |..||  |:.::..||....|. ::.|||:     :|..|.|..:.|  :.
  Fly   205 TEMILLRGPTKAELFRTLG--KVRFERRNEEGALKA-YQAALKHSPHDLEIFQEYQNLKRRVLTL 266

  Fly   270 APRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWLYHQGVPYYRLSPFKIEQLNV 334
            :|.:.:......:.|:.|.....:..|.|     ||:...|.|.......|:.||:|.|.|.|:|
  Fly   267 SPSEPIREEPNDDIEEMELPPCCSGRCEG-----PRKLNRLYCVYNCVTAPFLRLAPIKTEILSV 326

  Fly   335 DPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENS-TTSEVRISRNTWLWYDANPWLSKIKQ 398
            ||:|..:|:::...|...|....|..:..|:...:.|. ..::.|.|::.|...|||....|:.|
  Fly   327 DPFVILLHDMVSHKEGALIRSSSKNQILPSETVNAANEFEIAKFRTSKSVWFDSDANEATLKLTQ 391

  Fly   399 RLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFSWKGNRLLTALFYLNDVALGGAT 463
            ||.:.|||..:.:||.|::||||||.:|.|||....|.....:...:||.|.|||||||..||||
  Fly   392 RLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFVNGYIDRLATTLFYLNDVPQGGAT 456

  Fly   464 AFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGSKWICNEWFHVGAQEFRRPCGLS 528
            .||.|.:.|.|..|::|:|||||:......||.|.||||:.||||:.::|.....|||||||..|
  Fly   457 HFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCPVIVGSKWVVSKWIDDKGQEFRRPCLRS 521

  Fly   529 SDEGKFL 535
            ..:.|:|
  Fly   522 RLDSKYL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	33/137 (24%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	70/168 (42%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	33/137 (24%)
		TPR_11	215..>259	CDD:290150	14/46 (30%)
		TPR_2	216..249	CDD:285020	11/35 (31%)
		P4Hc	340..507	CDD:214780	69/166 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461966
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900