Protein Alignment PH4alphaSG1 and P4HA3

DIOPT Version :9

• Sequence 1: NP_733376.1
• Gene: PH4alphaSG1 / 326112
• FlyBaseID: FBgn0051014
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 176/589 - (29%)
• Similarity: 266/589 - (45%)
• Gaps: 76/589 - (12%)

  Fly     3 RLSIILSLLCV-------FPVNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLD 60
            ||:.:|::|.:       ....||.:||::.:.|.|..|..::.....||...:....:|.||.|
Human     6 RLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYD 70

  Fly    61 QIDEQQNDRGDLEEYFGNPINAFITIKRLVHDWKFNVFDPVFDSSNFETYKNNLSDSLEKINFKG 125
            ::.....|.   .....||:.||..||||..||: ||...:..|.|...    |.|..||:....
Human    71 KVLSLHEDS---TTPVANPLLAFTLIKRLQSDWR-NVVHSLEASENIRA----LKDGYEKVEQDL 127

  Fly   126 PTQEDLHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGT--------SLSASDCFELGKNLC 182
            |..|||.||.|||:|||::|.||...||.||......:|:..        ||:..|||::||...
Human   128 PAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAY 192

  Fly   183 EIKEYSYGSEWLLEARKRLHGKPLGFISPNVSDVE-ILEHLSSAFNGLGNLKLAYKLNNEILDKK 246
            ::.:|.:...||.||.....|....:.:.:.:.:| .|:||:.|:...||:..|..|:.|.|...
Human   193 DMGDYYHAIPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYS 257

  Fly   247 PDHEEALKNKILYEGQLARERSFAPRKQV-ELPQIAEKEQKESYKLYTQVCRGE--LHQSPREQR 308
            ||::...:|.:.||..||...:....:.| :.|.|...:.:::|:...|....:  |:|.|
Human   258 PDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIP---- 318

  Fly   309 NLRCWLYHQGVPYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENST 373
            :|.|........|..|.|.:.|.::::||:|..|:.:.|||...|.|..:..::||.|...|...
Human   319 SLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVVASGEKQL 383

  Fly   374 TSEVRISRNTWLWYDANPWLSKIKQRLEDVTGLSTES--AEPLQLVNYGIGGQYEPHFDFVEDDG 436
            ..|.|||::.||....:|.|..:..|:..:|||....  ||.||:|||||||.||||||......
Human   384 QVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYEPHFDHATSPS 448

  Fly   437 QSVFSWK-GNRLLTALFYLNDVALGGATAFPFLRLAVP------------PVKG-------SLLI 481
            ..::..| |||:.|.:.||:.|..||||||.:..|:||            .|||       ::|.
Human   449 SPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRHCFGGTCTGVVKGTVTHFMLAVLS 513

  Fly   482 WYNL-----HSSTHKDFRTKHAGCPVLQGSKWICNEWFH-------------VGAQEF-----RR 523
            |:.:     ......|..:.....|.|:........|:.             ||.::.     ||
Human   514 WWEISGWPTSGYMSMDRNSADPAAPALKTELLAERSWWSPVAFQRSQEPKAGVGEEKAEQPPGRR 578

  Fly   524 PCGL 527
            ||.|
Human   579 PCQL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	47/133 (35%)
		P4Hc	347..515	CDD:214780	64/194 (33%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	41/108 (38%)
		TPR_12	186..252	CDD:290160	17/65 (26%)
		P4Hc	356..>478	CDD:214780	50/121 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.800