Protein Alignment PH4alphaSG1 and p4ha1

DIOPT Version :10

• Sequence 1: NP_733376.1
• Gene: PH4alphaSG1 / 326112
• FlyBaseID: FBgn0051014
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_031761963.1
• Gene: p4ha1 / 100490484
• XenbaseID: XB-GENE-987760
• Length: 526
• Species: Xenopus tropicalis
• Alignment Length: 547
• Identity: 192/547 - (35%)
• Similarity: 294/547 - (53%)
• Gaps: 40/547 - (7%)

  Fly     3 RLSIILSLLCVFP-VNGDYYSAISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDE-Q 65
            ::.::|.||.:|. .:.|::::|..:..||:.|..:|....:|::..:|:...:|::.|::|. .
 Frog     2 KIHLVLPLLGLFSCAHADFFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLT 66

  Fly    66 QNDRGDLEEYFGNPINAFITIKRLVHDW-KFN--VFDPVFDSSNFETYKNNLSDSLEKINFKGPT 127
            .....|.|.|.|:|:|||..:|||..:| |..  :...:.|.     :.:||  ::::..|  |.
 Frog    67 DTATKDPEGYLGHPVNAFKLMKRLNTEWVKLENLILKDISDG-----FISNL--TIQRQYF--PN 122

  Fly   128 QEDLHGATRALLRLQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSE 192
            .||..||.:||||||:.|.|:||.::.|.| ||.|:.  |||:|.|||:|||......:|.:...
 Frog   123 DEDQTGAAKALLRLQDTYNLDTDTISKGNL-PGVKHK--TSLTAEDCFDLGKTAYTDADYYHTEL 184

  Fly   193 WLLEARKRLHGKPLGFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALKNKI 257
            |:.:|..:|....    ..::..|.:|::||.|....|:|..|..|....|:..|:|:....|..
 Frog   185 WMEQALSQLDAGE----ESSLDKVMVLDYLSYAVYQQGDLDKALTLTKRSLELDPEHQRGNGNLR 245

  Fly   258 LYEGQLARERSFAPRKQVEL------PQIAEKEQKESYKLYTQVCRGE-LHQSPREQRNLRCWLY 315
            ....:.:.:.|.:|.:..||      |    |:..|..| |.::|||| :..:.|.|:.|.| .|
 Frog   246 HIMSKESNKSSSSPSEGAELRTRKGRP----KDHLEKEK-YEKLCRGEGVKMTSRRQKRLFC-RY 304

  Fly   316 HQGV--PYYRLSPFKIEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKVGQSENST--TSE 376
            ..|.  |...|||.|.|.....|.:...|:::.|.||..:.|..|..:.|:.:.......  |::
 Frog   305 FDGKKDPLLILSPTKQEDEWDKPRIVRYHDIISDEEISKVKELAKPRLRRATISNPITGVLETAQ 369

  Fly   377 VRISRNTWLWYDANPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFS 441
            .||:::.||....:|.::::.:|:|.||||...:||.||:.||||||||||||||:.......|.
 Frog   370 YRITKSAWLSGYEDPVVARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFK 434

  Fly   442 --WKGNRLLTALFYLNDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQ 504
              ..|||:.|.|||::||..||||.||.:..||.|.||:.:.||||..|...|:.|:||.||||.
 Frog   435 KLGTGNRVATWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLV 499

  Fly   505 GSKWICNEWFHVGAQEFRRPCGLSSDE 531
            |:||:.|:|.|...|||||||.||..|
 Frog   500 GNKWVSNKWIHERGQEFRRPCNLSELE 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG1	NP_733376.1	P4Ha_N	23..159	CDD:462433	44/139 (32%)
		P4Hc	347..515	CDD:214780	75/171 (44%)
p4ha1	XP_031761963.1	P4Ha_N	23..154	CDD:462433	44/140 (31%)
		NrfG	181..>244	CDD:443378	15/66 (23%)
		P4Hc	337..510	CDD:214780	75/172 (44%)