DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and CG34345

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	154/521 - (29%)
Similarity:	251/521 - (48%)	Gaps:	74/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPL 89
            |..:|.|:..:..|.|:|...:::|.||.:.|:||::.:|..:..:.......:.:...|:||||
  Fly    34 EVIYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPL 98

  Fly    90 NGFSIIRRLHQDWINWRKYMEQ----PVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDL 150
            |.|.::||.||||.....|::.    .|.|.::....   :..|...|:.:|..|:.||:..|||
  Fly    99 NSFGLLRRAHQDWPKLIAYLKDQGNIKVDIEEMNKLI---NRTPHANDMEEALMGMDRIEHFYDL 160

  Fly   151 KVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQ---EVPQRLQEELLIQ---P 209
            |..|...|.:.|:|.:..||.:|.|::..|::.::....|.:|.:   .|..:.:..:..:   |
  Fly   161 KSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAP 225

  Fly   210 RHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARVLRLWKKTTDFIENQPDQSPTE 274
            :...::::..:..|.|..:::         |.:|||....|        .....:..:|.:|||
  Fly   226 KRKELEKMFVISRLQEGSVEN---------LTDCLKELSQD--------PNNSLVHLRPRKSPT- 272

  Fly   275 NKKRNVPIANAFKLSCNGPLESSTRLHCFYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSARE 339
                      ..:..|.|......:|.|.||.|||||:|:||||.|:|..||.:.|||:|:...|
  Fly   273 ----------MIEQGCQGKFPPGPQLVCRYNSTTTPFMRIAPLKEEEISRDPLIWLYHDVIYDSE 327

  Fly   340 ISMLIGKAAQNMKNTKIHKERAVPKKNRG-----RTAKGFWLK---KESNELTKRITRRIMDMTG 396
            |:.|          |.:.:|..:......     |..:.|.:|   .:..:|.|.:..|:.|::|
  Fly   328 IAQL----------TNVTREEMILGTTTNYTTPDRVNRLFHIKVTDDDGGKLDKTLVNRMADISG 382

  Fly   397 FDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYS--IDLGDRIATVLFYLTDVEQGG 459
            .|:.::.....||||:||::..|.||.|.         ..|.  .:.|||:.|.|||:|||..||
  Fly   383 LDVGNTTTLARINYGLGGYFQEHSDYMDI---------KLYPELTEEGDRLMTFLFYMTDVPVGG 438

  Fly   460 ATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPR--TRHAACPVIVGSKWVMTEWIREKRQIFIRP 522
            .|:|......:.|:.|:|:|||||  ..||||.  ||||.||.||||:||:.:.:....|:|.:|
  Fly   439 TTIFPGAQLAIQPKKGSALFWYNL--HNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKP 501

  Fly   523 C 523
            |
  Fly   502 C 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	39/132 (30%)
		TPR_11	178..248	CDD:290150	11/75 (15%)
		TPR repeat	211..246	CDD:276809	5/34 (15%)
		P4Hc	336..513	CDD:214780	63/188 (34%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	39/132 (30%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	63/185 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461717
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910