DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	572	Identity:	164/572 - (28%)
Similarity:	259/572 - (45%)	Gaps:	87/572 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYFIRC--LLVMLFHSTLVLGHRPLEKSHS---LSLVTMVPLLELEKKLIDNLENYTNALEQKL 60
            ||....|  ||:.|..|:         .:||   .|:..|..||..||.|:.:|::|..|.|.||
Zfish     2 MGVRSVCCFLLISLLKSS---------SAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKL 57

  Fly    61 EIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWK 125
            |.::.....:.|......::...:|.:|:|.|.:::||:.:|......:.:.:....:......:
Zfish    58 EQVKQWAEKLDALTATAVQDPEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKDMSDGFISNLTIQR 122

  Fly   126 DELPTERDLWDACEGIARIQSTYDLKVGDFINGNI----NGKQYNDSMSTADILSVGAYLFMKNR 186
            ...|.:.|...|.:.:.|:|.||.|......:|::    .|..|..:::..|...:|...:
Zfish   123 QYFPNDEDQNGAAKALLRLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAY---- 183

  Fly   187 PSDAIQ-----WLQEVPQRLQEELLIQPRHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKL 246
             |||..     |:.:..::|.|     .....::...||..|:.:..:......||......|.:
Zfish   184 -SDADYYHTELWMAQALKQLDE-----GEESSVEIATALDYLSYSVYQQGELERALEYTKRLLTV 242

  Fly   247 QPHDARVL--------------RLWKKTTDFIENQPDQSPTENKKRNVPIANAFKLSCNGP-LES 296
            :|...|.|              :..|:.:...|::.:|..::.||..:|....::..|.|. |:.
Zfish   243 EPEHQRALGNLKYFDYQLAKQKKAEKEQSTKEESKKEQETSDGKKEYLPEKRKYEKLCRGEGLKM 307

  Fly   297 STR----LHC-FYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKI 356
            :.|    |.| ::|....||..:.|:|.|.....|.::.|||:::.:||..:
Zfish   308 TPRRQKHLFCRYFNGNRHPFYTIGPVKQEDEWDRPRIIRYHEIITEQEIEKI------------- 359

  Fly   357 HKERAVPKKNRG---------------RTAKGFWLKKESNELTKRITRRIMDMTGFDLADSEGFQ 406
             ||.:.|:..|.               |.:|..||....:.:..||.:||.|:||.::..:|..|
Zfish   360 -KELSKPRLRRATISNPITGVLETAHYRISKSAWLAAYEHPVVDRINQRIEDITGLNVKTAEELQ 423

  Fly   407 VINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGYYVS 471
            |.|||:||.|..|   |||...:..|...  .:..|:||||.|||::||..||||||.:||..|.
Zfish   424 VANYGVGGQYEPH---FDFGRKDEPDAFK--ELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVK 483

  Fly   472 PQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523
            |..|||:|||||...|.||..||||||||:||:|||..:||.|:.|.|.|||
Zfish   484 PLKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFRRPC 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	31/128 (24%)
		TPR_11	178..248	CDD:290150	13/74 (18%)
		TPR repeat	211..246	CDD:276809	6/34 (18%)
		P4Hc	336..513	CDD:214780	76/191 (40%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	31/128 (24%)
		TPR repeat	172..207	CDD:276809	8/44 (18%)
		TPR repeat	212..242	CDD:276809	6/29 (21%)
		Fis1	218..262	CDD:304536	7/43 (16%)
		P4Hc	352..525	CDD:214780	76/191 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850