DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and P4HTM

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	312	Identity:	74/312 - (23%)
Similarity:	104/312 - (33%)	Gaps:	119/312 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 VLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG---RTAKGFWL--KKESNELTKRITRRIMD 393
            |||.:|.|        ||.....||.....|....   |.:...||  .:.::.:.:.|.:|::.
Human   243 VLSLQEFS--------NMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLR 299

  Fly   394 MTGF--DLAD-SEGFQVINYGIGGHYFLHMD---YFDFASSNHTDTRSRYSIDL----------- 441
            :|..  ::.: ||..||:.||.||||..|:|   .:.....:||...:..|:..
Human   300 LTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNW 364

  Fly   442 ----------------------------GDR------------------------IATVLFYLTD 454
                                        ||.                        ..||||||.:
Human   365 GLPSILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNN 429

  Fly   455 VEQGGATVF---------------GDV------------GYYVSPQAGTAIFWYNLDTDGNG--- 489
            |..||.|||               .||            ...|.||.|||:||||...||.|
Human   430 VTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVG 494

  Fly   490 --DPRTRHAACPVIVGSKWVMTEWI-----REKRQIFIRPCLPKAKGTSTKS 534
              |..:.|..|.|..|:||:...||     |.::.:|.:.....|:...|.|
Human   495 DVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDS 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528
		TPR_11	178..248	CDD:290150
		TPR repeat	211..246	CDD:276809
		P4Hc	336..513	CDD:214780	67/287 (23%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	5/16 (31%)
		EFh	194..252	CDD:238008	5/16 (31%)
		P4Hc	246..519	CDD:214780	64/280 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740