DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and P4HA1

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_000908.2	Gene:	P4HA1 / 5033	HGNCID:	8546	Length:	534	Species:	Homo sapiens

Alignment Length:	519	Identity:	157/519 - (30%)
Similarity:	250/519 - (48%)	Gaps:	40/519 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSII 95
            |:..|..|:..||.|:.:|::|..|.|.|||.|:.....:........::...::.:|:|.|.::
Human    24 SIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLM 88

  Fly    96 RRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDLKVGDFINGNI 160
            :||:.:|......:.:.:....:......:...|.:.|...|.:.:.|:|.||:|.......||:
Human    89 KRLNTEWSELENLVLKDMSDGFISNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNL 153

  Fly   161 NGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRHLPIKEVDALRLLAE 225
            .|.::...::..|...:|...:.:........|:::..::|.|..:     ..|.:|..|..|:.
Human   154 PGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEI-----STIDKVSVLDYLSY 213

  Fly   226 AQIKDQNYSEALPLLHNCLKLQPHDARV---LRLWK----KTTDF----IENQPDQSPTENKK-- 277
            |..:..:..:||.|....|:|.|...|.   |:.::    |..|.    .::|.||..|..||
Human   214 AVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGV 278

  Fly   278 --RNVPIANAFKLSCNGPLESST-----RLHC-FYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEV 334
              ..:|....:::.|.|.....|     :|.| :::....|...|||.|.|.....|.::.:|::
Human   279 AVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDI 343

  Fly   335 LSAREISMLIGKAAQNMKNTKIHKERAVPKKNRGRTA-----KGFWLKKESNELTKRITRRIMDM 394
            :|..||.::...|...:....:|.    |:..:..||     |..||....|.:..||..||.|:
Human   344 ISDAEIEIVKDLAKPRLSRATVHD----PETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDL 404

  Fly   395 TGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGG 459
            ||.|::.:|..||.|||:||.|..|   ||||..:..|...  .:..|:||||.|||::||..||
Human   405 TGLDVSTAEELQVANYGVGGQYEPH---FDFARKDEPDAFK--ELGTGNRIATWLFYMSDVSAGG 464

  Fly   460 ATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523
            ||||.:||..|.|:.|||:|||||...|.||..||||||||:||:|||..:|:.|:.|.|.|||
Human   465 ATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	29/128 (23%)
		TPR_11	178..248	CDD:290150	14/69 (20%)
		TPR repeat	211..246	CDD:276809	9/34 (26%)
		P4Hc	336..513	CDD:214780	80/181 (44%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	19/86 (22%)
		TPR	205..238		10/32 (31%)
		P4Hc	345..518	CDD:214780	80/181 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920