DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and PH4alphaPV

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	227/524 - (43%)
Similarity:	321/524 - (61%)	Gaps:	19/524 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VMLFHSTLVLGHRPL--EKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRA 72
            |:|.:..|:|..|..  |:||..|:..||.||:||.:||||||:|...||:||:.:|..:..:|.
  Fly    12 VLLTYQVLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRL 76

  Fly    73 ENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERDLWDA 137
            ||:|.|.:...|||||||.||:|||:::|||.|:.||:.||||.|::.....::.:||..|:.:|
  Fly    77 ENDKARSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTHTDVEEA 141

  Fly   138 CEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQ 202
            ...:.||||||.|||.:..:|.:||||||.|::..|..::|..||.:.....|..|:.:....::
  Fly   142 VTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQSVVLME 206

  Fly   203 EELLIQPRHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARVLRLWKKTTDFIENQ 267
            ...:..|  |.|.:.:...:.||..:|...:::||.:::..|...|||.::|....:....|...
  Fly   207 AFSMAAP--LEISKNEVRMVYAETLLKLNQHADALKVVNIALTDNPHDIKLLLKKSEIETMIRTG 269

  Fly   268 PDQSPTENKKRNVPIANAFKLSCNG--PLESSTRLHCFYNFTTTPFLRLAPLKTEQIGLDPYVVL 330
            .:.:|.. |.:...:..|:::.|.|  |..:.::|:|.||.||:|||.|||||.|.:|||||:||
  Fly   270 TNNAPPV-KVQATGVPTAYQIGCRGQFPPSADSKLYCLYNRTTSPFLILAPLKMELVGLDPYMVL 333

  Fly   331 YHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKN---RGRTAKGFWLKKESNELTKRITRRIM 392
            ||:|||.:||..|.|.|...:|...::  :|...:|   :.||:|..|.....|.||.|:..||.
  Fly   334 YHDVLSPKEIKELQGMATPGLKRATVY--QASSGRNEVVKTRTSKVAWFPDGYNPLTVRLNARIS 396

  Fly   393 DMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQ 457
            |||||:|..||..|::|||:||||..|.|:|:..:||.|...       ||||||||||||||||
  Fly   397 DMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTAMS-------GDRIATVLFYLTDVEQ 454

  Fly   458 GGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRP 522
            ||||||.::...|.||.|:.:.||||..:|..|.:|.|||||||||||||..:||||:.|||.||
  Fly   455 GGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQIFSRP 519

  Fly   523 CLPK 526
            ||.|
  Fly   520 CLKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	61/128 (48%)
		TPR_11	178..248	CDD:290150	14/69 (20%)
		TPR repeat	211..246	CDD:276809	8/34 (24%)
		P4Hc	336..513	CDD:214780	88/179 (49%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	61/128 (48%)
		TPR_11	179..250	CDD:290150	14/72 (19%)
		TPR repeat	179..213	CDD:276809	5/33 (15%)
		TPR repeat	218..248	CDD:276809	6/29 (21%)
		P4Hc	339..510	CDD:214780	88/179 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461772
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910