DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and CG9698

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	165/539 - (30%)
Similarity:	266/539 - (49%)	Gaps:	43/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLVMLFHSTL--VLGHRPLEKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVI 70
            :|.:|||..:  |.|.......|.     |..:...|:|::.:::.:.:..:.||:.::::|...
  Fly     8 VLFLLFHQAIPSVSGVEFFSSIHE-----MTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREF 67

  Fly    71 RAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVG---IWQLKAFYSWKDELPTER 132
            ..|..:.|....||..:|:|.:.:.:||..||......|....|   :.:|:.|.: ::.:|.::
  Fly    68 ENERNEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRN-RETMPDKK 131

  Fly   133 DLWDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEV 197
            :|..|.:|:.|:|..|.||..|...|.::|..|...:::...:.:.........|..|..||.|.
  Fly   132 ELEGAIDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRDQHPRLAHSWLIEA 196

  Fly   198 PQRL---QEELLIQPRHLPIKEVDALRLLAEAQIKD-----QNYSEALPLLHNCLKLQPHDARVL 254
            ..||   ::|..::|:.|      ||.:.|:.:::|     ..|.|.:.:.....:...:....|
  Fly   197 NDRLTGGEKEEQLKPQIL------ALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFL 255

  Fly   255 RLWKKTTDFIENQP--DQSPTENKKRNVPIANAFKLSCNG-----PLESSTRLHCFYNFTTTPFL 312
            ....:.....|::|  :.:|...:...|....|:.|:|:|     |.| ...|.|.|...|.|||
  Fly   256 NALSEKALLNESKPILEHAPIPEEGEPVGEFQAYSLTCSGHWRLTPKE-QRHLRCGYVTETHPFL 319

  Fly   313 RLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQN--MKNT-KIHKERAVPKKNRGRTAKGF 374
            .:||||.|::..||.:||||:|:...||. :|.|..:|  |:.| ..|.|..|   :..||::..
  Fly   320 WIAPLKAEELFQDPLLVLYHDVIYQSEID-VIRKLTENRLMRATITSHNESVV---SNVRTSQFT 380

  Fly   375 WLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSI 439
            ::...::::...|.:|:.|||..::..:|..|..||||||||..|||:|   .....|.....|.
  Fly   381 FIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWF---YQTTFDAGLVSSP 442

  Fly   440 DLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGS 504
            ::|:|||||||||:||.|||.|.|..:...:.|:...|.||:||...|.||.||:|.|||:|.||
  Fly   443 EMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAGS 507

  Fly   505 KWVMTEWIREKRQIFIRPC 523
            |||...||||..|...|||
  Fly   508 KWVQNRWIRENDQSDRRPC 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	31/131 (24%)
		TPR_11	178..248	CDD:290150	16/77 (21%)
		TPR repeat	211..246	CDD:276809	7/39 (18%)
		P4Hc	336..513	CDD:214780	72/179 (40%)
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	32/136 (24%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	72/177 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461884
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910