DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and PH4alphaNE2

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	186/548 - (33%)
Similarity:	285/548 - (52%)	Gaps:	52/548 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FIRCLLVMLFHSTLVLG---HRPLEKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRS 65
            |.|.:|:.:.:.:|..|   ....::..:.|:|.|..:|.||..|:.|:|....||.:|.:.|:.
  Fly     3 FWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKW 67

  Fly    66 QLLVIRAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPT 130
            .:..:....:: .::::...:||::.||:||.:..:|:.|..|:|.|||..:|....|....||.
  Fly    68 GVFKMMKRRQE-YKSSMEIFANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPK 131

  Fly   131 ERDLWDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWL- 194
            ..|..||.|||.::|:||.:...|...|.::|.|||.|:...|.|::|.:|...:|...|.||:
  Fly   132 YFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWIS 196

  Fly   195 ------QEVPQRLQEELLIQPRHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARV 253
                  .:...:...|||..|     |..|..|:|.:.|:|.:|:..||......|||.|||..:
  Fly   197 ASIEAYDQKSSQTDMELLRGP-----KLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEI 256

  Fly   254 LR----LWKKTTDFIENQPDQSPTENKKRNVPIANAFKLSCNGPLESSTRLHCFYNFTTTPFLRL 314
            ..    |.|:.....:.:|.:...:|....:.:.......|..| .:.:.|:|.||..|:|||:|
  Fly   257 YEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCSGRCQVP-RNLSNLYCVYNHVTSPFLQL 320

  Fly   315 APLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG----------- 368
            ||:|||.:.:||:|||.|:::|.:| |.||..::         ||..:|.....
  Fly   321 APIKTEILSIDPFVVLLHDMISQKE-STLIRTSS---------KEHMLPSATTDPDASDDETQVD 375

  Fly   369 --RTAKGFWLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHT 431
              ||:|..|...:.|:.||:||.|:.|.||.|:..:|.:||||||:||.:..|:|..       .
  Fly   376 TYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDML-------L 433

  Fly   432 DTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHA 496
            ..::|:: ...|||||.||||.:|.|||.|.|..:...|.||.|:|:|||||||.||....:.|.
  Fly   434 SEKNRFN-GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHT 497

  Fly   497 ACPVIVGSKWVMTEWIREKRQIFIRPCL 524
            .|||||||||||::||.:..|.|.|||:
  Fly   498 GCPVIVGSKWVMSKWINDMGQEFTRPCV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	41/128 (32%)
		TPR_11	178..248	CDD:290150	22/76 (29%)
		TPR repeat	211..246	CDD:276809	10/34 (29%)
		P4Hc	336..513	CDD:214780	76/189 (40%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	41/128 (32%)
		TPR repeat	175..200	CDD:276809	7/24 (29%)
		TPR_16	176..254	CDD:290168	25/82 (30%)
		TPR repeat	219..249	CDD:276809	9/29 (31%)
		TPR_2	220..253	CDD:285020	12/32 (38%)
		P4Hc	342..513	CDD:214780	75/188 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461720
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910