DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	163/553 - (29%)
Similarity:	259/553 - (46%)	Gaps:	81/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLVMLFHSTLVLGHRPLEKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIR 71
            ||.:.:|...:.:|....|...|:.  :|..|.::|::|::...:|..:.:::|:..|..:..|:
  Fly     6 CLYIGIFQLIIWVGVANGEFYSSVD--SMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIK 68

  Fly    72 AENE--KGRRNAISYLSNPLNGFSIIRRLHQDW----------INWRKYMEQPVGIWQLKAFYSW 124
            .|:|  ..:.....||.:||:.|.:|:||.:||          .|.|:.....|.:......|
  Fly    69 REHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGY-- 131

  Fly   125 KDELPTERDLWDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSD 189
                |.:.:|..|.:|:||:|..|:|...|..:|.|.|..|...:...:...:|..||.......
  Fly   132 ----PDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQR 192

  Fly   190 AIQWLQEVPQRLQEELLIQPRHLPIKEVDALRLLAE-------AQIKDQNYSEALPLLHNCLKLQ 247
            :::|||..        .|..|:.|.:|.||...|::       |..:..|..:|..||...|:.|
  Fly   193 SLEWLQVA--------FILLRNSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQ 249

  Fly   248 P-HDARVLRLWKKTTDFIENQPDQSPTENKKRNVP--IANAFKLSCNG---PLE-SSTRLHCFYN 305
            | |.|      ::|..::|:   :.|.:|.:...|  .:|..:| |.|   |.| |...|.|:.:
  Fly   250 PTHSA------QQTQKYLES---RVPGKNVQETKPSWFSNYTRL-CQGRRLPEERSGDPLRCYLD 304

  Fly   306 FTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG-- 368
            .....:..||||:.|.:.|||.:.:||.:||:::|..:..:|         .||..|.....|
  Fly   305 GKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEA---------DKEEMVRSAVAGSG 360

  Fly   369 --------RTAKGFWLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDF 425
                    |.::..||..:| .:...:.|.|..::|||:|.:|..||.|||:||.|..|.|||:.
  Fly   361 GEGTVRDLRVSQQTWLDYKS-PVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEV 424

  Fly   426 ASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGD 490
            ....:.:         ||||:|.:|||:||||||.|||..:..::.|..|..:.|:||....:.|
  Fly   425 NLPKNFE---------GDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVD 480

  Fly   491 PRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523
            .||.||.||||||||.:...|:....|.|.|||
  Fly   481 ARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRPC 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	35/140 (25%)
		TPR_11	178..248	CDD:290150	19/76 (25%)
		TPR repeat	211..246	CDD:276809	11/41 (27%)
		P4Hc	336..513	CDD:214780	66/186 (35%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	36/142 (25%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	66/186 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461788
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910