DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and CG11828

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	145/515 - (28%)
Similarity:	235/515 - (45%)	Gaps:	85/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 MVPLLELEKKLIDNLENYTNALEQKLEIIRS---QLLVIRAENEKGRRNAISYLSNPLNGFSIIR 96
            |..||::|.:||..:..|...|:.|:..:|:   :.:..||   .|..:..||::|||..|.::|
  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRA---LGPADPTSYVANPLISFPLMR 62

  Fly    97 RLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDLKVGDFINGNIN 161
            |.:.|.....:...:.......:.|..:.....::.:|..|..|:.|.|..|.:...:..||.::
  Fly    63 RTYTDVPKLLELAREEFKPGPFQKFIDYDLSSISDVELETAVTGMLRFQGVYGMDESEMANGKLH 127

  Fly   162 GKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEEL-----LIQPRHLPIKEVDALR 221
            |||||..||.||.|:|..:|...::...|.:|.:....:.:|:|     |:|.....|.|...|.
  Fly   128 GKQYNSRMSAADCLAVATHLENVDKGKLACKWFKVAIDQYEEKLDPVNRLLQTGRSQIYEKLGLT 192

  Fly   222 LLAEAQIKDQNYSEALPLLHNCLKLQPHDARVLRLWKKTTDFIENQPDQSPTENKKRNVPIANAF 286
            |||               :|:.    |......|             |.....:|:.|..:|...
  Fly   193 LLA---------------MHDL----PASQAAFR-------------DSIGWASKEDNTDLAKHL 225

  Fly   287 K----------LSCNGP--LESSTRLHCFYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSARE 339
            |          .:|.|.  |.|.:.|.|.|....:||||:||:|.||:.::|:|.|:|:.:|..|
  Fly   226 KDKLAHMFVHVDNCRGKNLLPSKSYLRCRYLRDGSPFLRMAPVKLEQLNIEPFVGLFHDAISPAE 290

  Fly   340 ISMLIGKAAQNMKNTKIHKERAVPKKNRGRTAKGFWLKKESNELTKRITRRIMDMTGFDLADSEG 404
            ...|:......:::.|        |.:....||   :...:::..:||.:||.|:|||||.:||.
  Fly   291 QKDLLHLTDSRLEHRK--------KDSSSVEAK---VDTNASDHVRRIHQRIEDITGFDLEESEP 344

  Fly   405 FQVINYGIGGHYFLHMD------YFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVF 463
            ..|.||||||..|:|:|      :..:....:             |.|:.:|||:||:.||...|
  Fly   345 LTVSNYGIGGQDFIHLDCEQPKEFIGYYPKEY-------------RSASAMFYLSDVQMGGYASF 396

  Fly   464 GDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523
            .|:|:...|:.|:|:.|:|.|..||.|.|:..|.|||::|::||..:||....|...:.|
  Fly   397 PDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSC 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	31/127 (24%)
		TPR_11	178..248	CDD:290150	14/74 (19%)
		TPR repeat	211..246	CDD:276809	7/34 (21%)
		P4Hc	336..513	CDD:214780	59/182 (32%)
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	31/127 (24%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	58/181 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461851
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900