DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and CG32199

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	163/534 - (30%)
Similarity:	270/534 - (50%)	Gaps:	65/534 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 HSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEII--------RSQLLVIRAENEKGRRNAISY 84
            :|.|:::|:.|||:|:.|..||:.|...::.||::|        |..|..:..:.|        |
  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEE--------Y 59

  Fly    85 LSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYD 149
            :|||||.|.::|||:|||..|.:|::..:...::|.........|.:.||..|.:|:.||:..::
  Fly    60 VSNPLNAFPMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHN 124

  Fly   150 LKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRH--- 211
            |...|...|.:.||:.|..::..|.:::|.|.:.:.:.|.:..|     .|:...:...||.
  Fly   125 LHAEDLTKGVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHW-----YRMALRVHTHPRGMIY 184

  Fly   212 ---LPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQP---HDARVLRLWKKTT-----DFIE 265
               |.:|.....:..|:|.:|:...|:         |.:|   ..:...||.|:.|     |.::
  Fly   185 AKVLGLKRKRIYKKYAKALLKESLNSD---------KSKPTPTEKSEWNRLAKEVTREDNYDNVK 240

  Fly   266 NQPDQSPTENKKRNVPIANAFK-------LSCNG--PLESSTRLHCFYNFTTTPFLRLAPLKTEQ 321
            ...|:..:.::|....:|...|       ..|.|  |.:||..|.|.||..|:.||:|||||.|.
  Fly   241 KLIDEYLSGDEKIFQEVAARLKRKPTKLERGCRGEWPKKSSPELICRYNRDTSAFLKLAPLKLEF 305

  Fly   322 IGLDPYVVLYHEVL------SAREISMLIGKAAQNMKNTKIHKERAVPKKNRGRTAKGFWLKKES 380
            :.:.|.::|||:||      |.|:|:|..|......  |.:..::....|.:.|..|....:..:
  Fly   306 LSVQPMILLYHDVLYENEFKSMRDIAMYNGSMIDGW--TYVDFDKKGNPKQQDRVVKMIAFQGTT 368

  Fly   381 NELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRI 445
            ...|..|.||:.||:|.::.|:....:.|||:|||:..|:||.:.| ....|..:.:.   ||||
  Fly   369 APFTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELA-KRPPDFFADFG---GDRI 429

  Fly   446 ATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTE 510
            ||.|.|.:|:..||.|||..:...|.|:.|:|:.|:||:..|..||.|.|:.|||::||:|::::
  Fly   430 ATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIISK 494

  Fly   511 WIREKRQIFIRPCL 524
            ||.|::|:|.:|||
  Fly   495 WIHERQQVFKKPCL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	42/136 (31%)
		TPR_11	178..248	CDD:290150	14/75 (19%)
		TPR repeat	211..246	CDD:276809	6/40 (15%)
		P4Hc	336..513	CDD:214780	61/176 (35%)
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	42/136 (31%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	52/131 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462012
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910