DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and CG18749

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	175/511 - (34%)
Similarity:	267/511 - (52%)	Gaps:	70/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPL 89
            :||::.|.:.::.|||:|.:|:|||:.|...|:.|..::...|:.:..||.:.:.:..|||.|||
  Fly    29 KKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPL 93

  Fly    90 NGFSIIRRLHQDWINWRKY--MEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDLKV 152
            |.|.:|.|||..|..|.:|  ..:...:..::.....:..|||..||..||.||..:...||||.
  Fly    94 NSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMYFYDLKP 158

  Fly   153 GDFINGNING-KQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRHLPIKE 216
            .:...||:.| .|....::..|.|::|.: .::|:..|
  Fly   159 EELAAGNLAGYSQPGTGLTAYDCLALGEF-GVQNQKDD--------------------------- 195

  Fly   217 VDALRLLAEAQIKDQNYSEALPLLHNCL-KLQPHDARVLRLWKK---TTDF--IENQPDQSPTEN 275
                  ||||.     |:.:|....|.: |.|.|.|..|.|.|.   |..|  .||:|:.....|
  Fly   196 ------LAEAW-----YNLSLTRFDNIIEKYQVHKAWALLLAKNKQLTEAFQHFENKPEGIVASN 249

  Fly   276 KKRNVPIANAFKLSCNGPLES-STRLHCFYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSARE 339
            :..:.....|...:|...::. |.:|||.||.:||||.|:||||.|::|||||:|::|:|:...|
  Fly   250 EVIHFEGVLATTQNCTAVVQKPSKKLHCRYNTSTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTE 314

  Fly   340 ISMLIGKAAQNMKNTKIHKERAVPKKNRGRTAKGFWLKKESNEL-TKRITRRIMDMTGFDLADSE 403
            |..::..:...:      .|.....|:..||:      |:|:.: .|.:..|:.||||..:..|:
  Fly   315 IDGMLNSSDFGL------SESVSGLKSEVRTS------KDSHIVDAKTLNERVTDMTGLSMEMSD 367

  Fly   404 GFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGY 468
            .|.:||||:|||:.||.|:.::.::    ||    :..|||||||||||.:|:.||||||..:..
  Fly   368 PFSLINYGLGGHFILHHDFHEYTNT----TR----LKQGDRIATVLFYLREVDSGGATVFPMLNI 424

  Fly   469 YVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPCL 524
            .|.|:.|:|:|||||...|..:.:|.|.|||||.|||:|:|:||.|..|:|:.||:
  Fly   425 TVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPCM 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	44/130 (34%)
		TPR_11	178..248	CDD:290150	11/70 (16%)
		TPR repeat	211..246	CDD:276809	7/35 (20%)
		P4Hc	336..513	CDD:214780	69/177 (39%)
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	44/130 (34%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	68/173 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461743
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890