DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and P4ha3

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	140/519 - (26%)
Similarity:	210/519 - (40%)	Gaps:	89/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSII 95
            :|.::...|..|::|:..|..|....|.:|..:......:.:.:|..:...:    |||..|::|
  Rat    33 ALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFYDKVLSLHEDLKIPVV----NPLLAFTLI 93

  Fly    96 RRLHQDWINWRKYMEQPVGIWQLKAFY-SWKDELPTERDLWDACEGIARIQSTYDLKVGDFING- 158
            :||..||.|....:|....|..||..| ..:.:||...||..|...:.|:|..|.|.|.....|
  Rat    94 KRLQSDWRNVVHSLEATENIRALKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGLAQGV 158

  Fly   159 --NINGKQYND--------SMSTADILSVGAYLFMKNRPSDAIQWLQEVPQ---------RLQEE 204
              .:.|....|        |::..|...||...:.......||.||:|...         :.::|
  Rat   159 FQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWLEEAVSLFRRSYGEWKTEDE 223

  Fly   205 LLIQPRHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARVLRLWKKTTDFIENQPD 269
            ..::         |||..||.|..:..|.|.||.|....|...|.:.|:.|...|....:.....
  Rat   224 ASLE---------DALDYLAFACYQVGNVSCALSLSREFLVYSPDNKRMARNVLKYERLLAENGH 279

  Fly   270 QSPTEN--KKRNVP---IANAFKLSCNGPLESSTR-----LHCFYNFTTTPFLRLAPLKTEQIGL 324
            ....|.  ::.|||   ..:.::..|.......|.     |:|.|...::|:|.|.|.:.|.|.|
  Rat   280 LMAAETAIQRPNVPHLQTRDTYEGLCQTLGSQPTHYQIPSLYCSYETNSSPYLLLQPARKEVIHL 344

  Fly   325 DPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG-------------RTAKGFWL 376
            .|.|.|||:.:|..|        ||.:      :|.|.|...|.             |.:|..||
  Rat   345 RPLVALYHDFVSDEE--------AQKI------RELAEPWLQRSVVASGEKQLQVEYRISKSAWL 395

  Fly   377 KKESNELTKRITRRIMDMTGFDLAD--SEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSI 439
            |...:.:...:.|||..:||.|:..  :|..||:||||||||..|.|:....||      ..|.:
  Rat   396 KDTVDPVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSS------PLYKM 454

  Fly   440 DLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDG--NGDPRTRHAACPVI 501
            ..|:|:||::.||:.||.||||.| ..|.:..|    .:.|   .|.|  :.|..:...|.|::
  Rat   455 KSGNRVATLMIYLSSVEAGGATAF-IYGNFSVP----VVKW---PTSGYTSMDRNSEDPAAPIL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	35/132 (27%)
		TPR_11	178..248	CDD:290150	19/78 (24%)
		TPR repeat	211..246	CDD:276809	12/34 (35%)
		P4Hc	336..513	CDD:214780	56/183 (31%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	19/77 (25%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	47/141 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750