DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31013 and P4ha2

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	162/539 - (30%)
Similarity:	247/539 - (45%)	Gaps:	81/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSII 95
            |:..|..|:..||.|:.:|:.|..|.|.||..|:|....:.|...|...:...||::|:|.:.::
  Rat    26 SIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAYKLV 90

  Fly    96 RRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDLKVGDFINGNI 160
            :||:.||......:.|......:......:...||:.|...|...:.|:|.||.|.......|.:
  Rat    91 KRLNTDWPALGDLVLQDAAAGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDMISRGEL 155

  Fly   161 NGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRHLPIKEVDA------ 219
            .|.:|...:|..|...:|...:.:......:.|:::|                :|::||
  Rat   156 PGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQV----------------LKQLDAGEEATV 204

  Fly   220 -----LRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARV---LRLWKKTTD-----FIENQPD-- 269
                 |..|:.|..:..:...|:.|....|.|.|...|.   ||.:::..:     .:.||.|
  Rat   205 TKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAG 269

  Fly   270 ----QSPTENKKRNVPIANAFKLSCNGPLESST-----RLHCFYNF-TTTPFLRLAPLKTEQIGL 324
                ::..|.....:|..:.::..|.|.....|     ||.|.|:. ...|.|.:||.|.|....
  Rat   270 LASQENLYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEEDEWD 334

  Fly   325 DPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG---------------RTAKGF 374
            .|::|.|::|:|..||..:              ||.|.||..|.               |.:|..
  Rat   335 SPHIVRYYDVMSDEEIERI--------------KEIAKPKLARATVRDPKTGVLTVASYRVSKSS 385

  Fly   375 WLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSI 439
            ||:::.:.:..|:.||:..:||..:..:|..||.|||:||.|..|   |||:.|:..|...|  :
  Rat   386 WLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPH---FDFSRSDERDAFKR--L 445

  Fly   440 DLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGS 504
            ..|:|:||.|.|::|||.||||||.|:|..:.|:.|||:|||||...|.||.|||||||||:||.
  Rat   446 GTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGC 510

  Fly   505 KWVMTEWIREKRQIFIRPC 523
            |||..:|..|:.|.|:|||
  Rat   511 KWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	35/128 (27%)
		TPR_11	178..248	CDD:290150	13/80 (16%)
		TPR repeat	211..246	CDD:276809	9/45 (20%)
		P4Hc	336..513	CDD:214780	78/191 (41%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	23/76 (30%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	78/191 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920