DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and P4ha3

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_006508007.1	Gene:	P4ha3 / 320452	MGIID:	2444049	Length:	551	Species:	Mus musculus

Alignment Length:	583	Identity:	171/583 - (29%)
Similarity:	243/583 - (41%)	Gaps:	98/583 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYFIRCLLVMLFHSTLVLGHRPL-----EKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKL 60
            ||...|..|:.|    |.||..|.     |.:.| :|.::...|..|::|:..|..|....|.:|
Mouse     1 MGPGARLALLAL----LALGGDPAAATGREDTFS-ALTSVARALAPERRLLGTLRRYLRGEEARL 60

  Fly    61 EIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFY-SW 124
            ..:......:.:.:|..:...:    |||..|::|:||..||.|....:|....|..||..| ..
Mouse    61 RDLTRFYDKVLSLHEDLKIPVV----NPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKV 121

  Fly   125 KDELPTERDLWDACEGIARIQSTYDLKVGDFING---NINGKQYNDSMSTADILSVGA-YLFMKN 185
            :.:||...||..|...:.|:|..|.|.|.....|   .:.|....|..|...:.|:.| ..|...
Mouse   122 EQDLPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSSITDLYSPRQLFSLTADDCFQVG 186

  Fly   186 RPS----------------DAIQWLQEVPQ---------RLQEELLIQPRHLPIKEVDALRLLAE 225
            :||                .||.||:|...         :.::|..::         |||..||.
Mouse   187 KPSCGSRSLQVAYDTGDYYHAIPWLEEAVSLFRRAHGEWKTEDEASLE---------DALDYLAF 242

  Fly   226 AQIKDQNYSEALPLLHNCLKLQPHDARVLRLWKKTTDFIENQPDQSPTEN--KKRNVP---IANA 285
            |..:..|.|.||.|....|...|.:.|:.|...|....:.....|...|.  ::.|||   ..:.
Mouse   243 ACFQVGNVSCALSLSREFLVYSPDNKRMARNVLKYERLLAENGHQMAAETAIQRPNVPHLQTRDT 307

  Fly   286 FKLSCNGPLESSTR-----LHCFYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIG 345
            ::..|.......|.     |:|.|...::|:|.|.|.:.|.:.|.|.:.|||:.:|..|
Mouse   308 YEGLCQTLGSQPTHYQIPSLYCSYETNSSPYLLLQPARKEVVHLRPLIALYHDFVSDEE------ 366

  Fly   346 KAAQNMKNTKIHKERAVPKKNRG-------------RTAKGFWLKKESNELTKRITRRIMDMTGF 397
              ||.:      :|.|.|...|.             |.:|..|||...:.:...:..||..:||.
Mouse   367 --AQKI------RELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPMLVTLDHRIAALTGL 423

  Fly   398 DLAD--SEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGA 460
            |:..  :|..||:||||||||..|.|:....||      ..|.:..|:|:||.:.||:.||.|||
Mouse   424 DIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSS------PLYRMKSGNRVATFMIYLSSVEAGGA 482

  Fly   461 TVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523
            |.|....:.|......|:||:||...|.||..|.||.|||:||.|||..:||.|..|.|.|||
Mouse   483 TAFIYGNFSVPVVKNAALFWWNLHRSGEGDGDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPC 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	35/132 (27%)
		TPR_11	178..248	CDD:290150	22/95 (23%)
		TPR repeat	211..246	CDD:276809	12/34 (35%)
		P4Hc	336..513	CDD:214780	68/191 (36%)
P4ha3	XP_006508007.1	P4Ha_N	31..157	CDD:369820	35/129 (27%)
P4ha3	XP_006508007.1	P4Hc	363..535	CDD:214780	68/191 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740