DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and P4HA3

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001275677.1	Gene:	P4HA3 / 283208	HGNCID:	30135	Length:	604	Species:	Homo sapiens

Alignment Length:	563	Identity:	147/563 - (26%)
Similarity:	220/563 - (39%)	Gaps:	120/563 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 STLVLG----HRPLEKSHSLSLVTMVP-LLELEKKLIDNLENYTNALEQKL-EIIRSQLLVIRAE 73
            :.|.||    .|...:..:.|.:|.|. .|..|::|:..|..|....|.:| ::.|....|:...
Human    12 AVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKVLSLH 76

  Fly    74 NEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFY-SWKDELPTERDLWDA 137
            .:     :.:.::|||..|::|:||..||.|....:|....|..||..| ..:.:||...||..|
Human    77 ED-----STTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDLEGA 136

  Fly   138 CEGIARIQSTYDLKVGDFING---NINGKQYND--------SMSTADILSVGAYLFMKNRPSDAI 191
            ...:.|:|..|.|.|.....|   .:.|....|        |::..|...||...:.......||
Human   137 ARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAI 201

  Fly   192 QWLQEVPQ---------RLQEELLIQPRHLPIKEVDALRLLAEAQIKDQNYSEALPLLHNCLKLQ 247
            .||:|...         :.::|..::         |||..||.|..:..|.|.||.|....|...
Human   202 PWLEEAVSLFRGSYGEWKTEDEASLE---------DALDHLAFAYFRAGNVSCALSLSREFLLYS 257

  Fly   248 PHDARVLRLWKKTTDFIENQPDQSPTEN--KKRNVP---IANAFK-----LSCNGPLESSTRLHC 302
            |.:.|:.|...|....:...|:....|.  ::.|:|   ..:.::     |.....|.....|:|
Human   258 PDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYC 322

  Fly   303 FYNFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNR 367
            .|...:..:|.|.|::.|.|.|:||:.|||:.:|..|        ||.:      :|.|.|...|
Human   323 SYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSE--------AQKI------RELAEPWLQR 373

  Fly   368 G-------------RTAKGFWLKKESNELTKRITRRIMDMTGFDLAD--SEGFQVINYGIGGHYF 417
            .             |.:|..|||...:.....:..||..:||.|:..  :|..||:||||||||.
Human   374 SVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYE 438

  Fly   418 LHMDYFDFASSNHTDTRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYN 482
            .|.|:....||      ..|.:..|:|:||.:.||:.||.||||.|               .:.|
Human   439 PHFDHATSPSS------PLYRMKSGNRVATFMIYLSSVEAGGATAF---------------IYAN 482

  Fly   483 LDTDGNGDPRTRH---AACPVIVG-----------SKWVMTEW 511
            |..     |..||   ..|..:|.           |.|.::.|
Human   483 LSV-----PVVRHCFGGTCTGVVKGTVTHFMLAVLSWWEISGW 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	38/134 (28%)
		TPR_11	178..248	CDD:290150	19/78 (24%)
		TPR repeat	211..246	CDD:276809	12/34 (35%)
		P4Hc	336..513	CDD:214780	57/205 (28%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	30/105 (29%)
		TPR_12	186..252	CDD:290160	19/74 (26%)
		P4Hc	356..>478	CDD:214780	46/141 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750