DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31013 and P4ha2

DIOPT Version :9

Sequence 1:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_006532515.1	Gene:	P4ha2 / 18452	MGIID:	894286	Length:	557	Species:	Mus musculus

Alignment Length:	558	Identity:	159/558 - (28%)
Similarity:	249/558 - (44%)	Gaps:	99/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSII 95
            |:..|..|:..||.|:.:|:.|....|.||..|:|....:.|...:...:...||::|:|.:.::
Mouse    28 SIGHMTDLIYAEKDLVQSLKEYILVEEAKLAKIKSWASKMEALTSRSAADPEGYLAHPVNAYKLV 92

  Fly    96 RRLHQDWINWRKYMEQPVGIWQLKAFYSWKDELPTERDLWDACEGIARIQSTYDLKVGDFINGNI 160
            :||:.||......:.|......:......:...||:.|...|...:.|:|.||.|.......|.:
Mouse    93 KRLNTDWPALGDLVLQDASAGFVANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDTISRGEL 157

  Fly   161 NGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRHLPIKEVDA------ 219
            .|.:|...:|..|...:|...:.:......:.|:::|                :|::||
Mouse   158 PGTKYQAMLSVDDCFGLGRSAYNEGDYYHTVLWMEQV----------------LKQLDAGEEATV 206

  Fly   220 -----LRLLAEAQIKDQNYSEALPLLHNCLKLQPHDARV---LRLWKKTTD-----FIENQPD-- 269
                 |..|:.|..:..:...|:.|....|.|.|...|.   ||.:::..:     .:.||.|
Mouse   207 TKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAG 271

  Fly   270 --------QSPTENKKRNVPIANAFKLSCNGPLESST-----RLHCFYNF-TTTPFLRLAPLKTE 320
                    :.||:    .:|..:.::..|.|.....|     :|.|.|:. ...|.|.:||.|.|
Mouse   272 LATQENLYERPTD----YLPERDVYESLCRGEGVKLTPRRQKKLFCRYHHGNRVPQLLIAPFKEE 332

  Fly   321 QIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG---------------RT 370
            .....|::|.|::|:|..||..:              ||.|.||..|.               |.
Mouse   333 DEWDSPHIVRYYDVMSDEEIERI--------------KEIAKPKLARATVRDPKTGVLTVASYRV 383

  Fly   371 AKGFWLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDY----FDFASS--- 428
            :|..||:::.:.:..|:.||:..:||..:..:|..||.|||:||.|..|.|:    ||....
Mouse   384 SKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRRPFDSGLKTEG 448

  Fly   429 -------NHTDTRSRYS-IDLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDT 485
                   |::|.:..:. :..|:|:||.|.|::|||.||||||.|:|..:.|:.|||:|||||..
Mouse   449 NRLATFLNYSDEQDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLR 513

  Fly   486 DGNGDPRTRHAACPVIVGSKWVMTEWIREKRQIFIRPC 523
            .|.||.|||||||||:||.|||..:|..|:.|.|:|||
Mouse   514 SGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	33/128 (26%)
		TPR_11	178..248	CDD:290150	13/80 (16%)
		TPR repeat	211..246	CDD:276809	9/45 (20%)
		P4Hc	336..513	CDD:214780	77/206 (37%)
P4ha2	XP_006532515.1	P4Ha_N	28..157	CDD:369820	33/128 (26%)
P4ha2	XP_006532515.1	P4Hc	348..541	CDD:214780	77/206 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920