DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf-like and TRAF4

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_011523806.1	Gene:	TRAF4 / 9618	HGNCID:	12034	Length:	477	Species:	Homo sapiens

Alignment Length:	223	Identity:	58/223 - (26%)
Similarity:	97/223 - (43%)	Gaps:	41/223 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 NVKNIVCETEE-----RCDKLDRALHQTMQNISDLETQMAMQQRIAS-----VQNIR-------- 333
            |...::|..::     ||.||..|.|..    ..::..:||...:.|     :|.:|
Human   251 NTALVLCPFKDSGCKHRCPKLAMARHVE----ESVKPHLAMMCALVSRQRQELQELRRELEELSV 311

  Fly   334 ---GHLIWRIKDYSKKLEESKQYDTI-LHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNV 394
               |.|||:|..|.::|:|:|....: ..|..|....:||.|::..:|||.|:.:|.::...:.|
Human   312 GSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRV 376

  Fly   395 LSGEYDPLLAWPCRLQAEIIIRDQC-TNVADAEDYVKTIFVRKKSDDF----------IQSNQYF 448
            |.|.:|.||.||...:....:.||. ..:|..:...:|........:|          .:|:..|
Human   377 LPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGF 441

  Fly   449 HIP----HKVITSRNYLRNDSMFIEVRV 472
            ..|    |:.|..|||:|:|::||...|
Human   442 GYPKFISHQDIRKRNYVRDDAVFIRAAV 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	45/155 (29%)
TRAF4	XP_011523806.1	RING	18..55	CDD:238093
		zf-TRAF	109..163	CDD:280357
		zf-TRAF	217..276	CDD:280357	7/24 (29%)
		MATH_TRAF4	315..470	CDD:239750	45/155 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810