Protein Alignment Traf-like and TRAF5

DIOPT Version :9

• Sequence 1: NP_727976.1
• Gene: Traf-like / 32611
• FlyBaseID: FBgn0030748
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_011508259.1
• Gene: TRAF5 / 7188
• HGNCID: 12035
• Length: 631
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 109/485 - (22%)
• Similarity: 191/485 - (39%)
• Gaps: 106/485 - (21%)

  Fly     9 RKDLTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNE---WFDAQTFTEHLIHCGQVLEECPNG 70
            ||||.|.              .:...::.|..||:|.:   ..:.|...|:|  |.:....|||.
Human   224 RKDLKEH--------------LSASCQFRKEKCLYCKKDVVVINLQNHEENL--CPEYPVFCPNN 272

  Fly    71 CQAFIPRIRMRSHLKECPRNQHNLS-NQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIR 134
            |...|.:..:..||..||..:.:.. .....:|:..|.:.|..:            .|.|.|.:|
Human   273 CAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHE------------HSALREHMR 325

  Fly   135 QRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSL 199
            ..|                       ||.:     |:||:.:                 |:.:||
Human   326 LVL-----------------------EKNV-----QLEEQIS-----------------DLHKSL 345

  Fly   200 KEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFF--QIEEFLQQINE 262
             ||.||::.:..:.:.:|..:..........|...|..:......:::..:.  |:.:.||.:|:
Human   346 -EQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQ 409

  Fly   263 -----DIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAM 322
                 |::..:...|.|..|...|:    |....:...||..:|     |.|..||.  :.|::.
Human   410 QQNKFDLRPLMEAVDTVKQKITLLE----NNDQRLAVLEEETNK-----HDTHINIH--KAQLSK 463

  Fly   323 -QQRIASVQN--IRGHLIWRIKDYSKKLEESKQYDTI-LHSAMFSNKAFGYALRLDIYLNGKGTW 383
             ::|...::.  ..|.|||::.||..|..|:....|: :.|..|.....||.|....||||.|:.
Human   464 NEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSG 528

  Fly   384 KGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQC--TNVADA--EDYVKTIFVRKKSDDFIQS 444
            :|.::.....|:.||:|.||.||.|.:..:::.||.  .|:.:.  .|...:.|.|...:..|.|
Human   529 RGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIAS 593

  Fly   445 NQYFHIPHKVI-TSRN-YLRNDSMFIEVRV 472
            .....:.|.|: .::| |:::|::|::|.|
Human   594 GCPRFVAHSVLENAKNAYIKDDTLFLKVAV 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	10/33 (30%)
		MATH_TRAF_C	334..473	CDD:238168	45/146 (31%)
TRAF5	XP_011508259.1	RING	109..145	CDD:214546
		zf-TRAF	202..257	CDD:280357	10/46 (22%)
		zf-TRAF	257..315	CDD:280357	15/59 (25%)
		MATH	478..624	CDD:295307	45/146 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7790
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910