DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Traf-like and TRAF2

DIOPT Version :9

Sequence 1:NP_727976.1 Gene:Traf-like / 32611 FlyBaseID:FBgn0030748 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_066961.2 Gene:TRAF2 / 7186 HGNCID:12032 Length:501 Species:Homo sapiens


Alignment Length:474 Identity:101/474 - (21%)
Similarity:180/474 - (37%) Gaps:127/474 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 TIVKYEKSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIRMRSHLK-ECPRNQHNLS 95
            |:.:||  ||              |...|..:|.||| .|:..:.......||: |||  :.:||
Human   117 TLKEYE--SC--------------HEGRCPLMLTECP-ACKGLVRLGEKERHLEHECP--ERSLS 162

  Fly    96 NQQ------------------RMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLI-- 140
            .:.                  :..::.|...::...|    |:....:::.....:..|.|.|  
Human   163 CRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPR----EKFQDHVKTCGKCRVPCRFHAIGC 223

  Fly   141 --TDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLD---VQYCCDITQSLK 200
              |..|..:::::|  .|.||      .|...:......|....:|:...   :|.|        
Human   224 LETVEGEKQQEHEV--QWLRE------HLAMLLSSVLEAKPLLGDQSHAGSELLQRC-------- 272

  Fly   201 EQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIK 265
            |.:|.:....:.:|..|:.:|        :.:....|......||:::|...:...:||:...|.
Human   273 ESLEKKTATFENIVCVLNREV--------ERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIG 329

  Fly   266 TKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASVQ 330
            .|                                   |.|:....|.:.::|         ||..
Human   330 LK-----------------------------------DLAMADLEQKVLEME---------ASTY 350

  Fly   331 NIRGHLIWRIKDYSKKLEE--SKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLN 393
            :  |..||:|.|:::|.:|  :.:...|...|.:::: :||.:.|.|||||.||.:|.::.....
Human   351 D--GVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSR-YGYKMCLRIYLNGDGTGRGTHLSLFFV 412

  Fly   394 VLSGEYDPLLAWPCRLQAEIIIRDQCT--NVADA--EDYVKTIFVRKKSDDFIQSNQYFHIPHKV 454
            |:.|..|.||.||...:..:::.||..  :|.||  .|...:.|.|..:|..|.|......|...
Human   413 VMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSK 477

  Fly   455 ITSRN-YLRNDSMFIEVRV 472
            :.::| |:|:|::||:..|
Human   478 MEAKNSYVRDDAIFIKAIV 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Traf-likeNP_727976.1 zf-TRAF_2 <54..88 CDD:292587 10/34 (29%)
MATH_TRAF_C 334..473 CDD:238168 46/146 (32%)
TRAF2NP_066961.2 RAD18 28..>157 CDD:333230 15/56 (27%)
RING-HC_TRAF2 32..73 CDD:319553
RING-HC finger (C3HC4-type) 34..72 CDD:319553
zf-TRAF 178..235 CDD:280357 8/60 (13%)
TRAF_BIRC3_bd 267..329 CDD:318808 13/77 (17%)
Important for interaction with BIRC2 and BIRC3. /evidence=ECO:0000250 283..293 2/9 (22%)
MATH_TRAF2 334..497 CDD:239747 51/175 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0297
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10131
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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