Protein Alignment Traf-like and TRAF1

DIOPT Version :10

• Sequence 1: NP_727976.1
• Gene: Traf-like / 32611
• FlyBaseID: FBgn0030748
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_005649.1
• Gene: TRAF1 / 7185
• HGNCID: 12031
• Length: 416
• Species: Homo sapiens
• Alignment Length: 460
• Identity: 104/460 - (22%)
• Similarity: 177/460 - (38%)
• Gaps: 123/460 - (26%)

  Fly    66 ECPNGCQAFI------PR-IRMRSHLKECPRNQHN-----LSNQQRMSVSM-DRLDRQSDQRLLV 117
            |.|.||...:      || :.....|.|.|||..:     ...:...|:|. .||..|......|
Human    17 EFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEV 81

  Fly   118 IEQDV------------GTIRSVLNEEI-RQRLHLITDVGNIRKQNQV-----VEDWTRETEKAM 164
            .|..:            |:.:||...|: .|..||...:| ..||.:.     :|......|:.:
Human    82 AEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLG-FMKQWKARLGCGLESGPMALEQNL 145

  Fly   165 DDLRRQ--------MEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADV 221
            .||:.|        :|.:..|...:..|.:|.:|:.  :.:.|..::|.:|...:.:|..|:.:|
Human   146 SDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHF--MKEKLLAELEGKLRVFENIVAVLNKEV 208

  Fly   222 ---------TYHQNQLN-DNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTS 276
                     :.||:||: :.||.||:.:.|               |||
Human   209 EASHLALATSIHQSQLDRERILSLEQRVVE---------------LQQ----------------- 241

  Fly   277 KQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASVQNIRGHLIWRIK 341
                          .:.:.::...||:::|                  |:....:..|..:|:|.
Human   242 --------------TLAQKDQALGKLEQSL------------------RLMEEASFDGTFLWKIT 274

  Fly   342 DYSKKLEESKQYDTI-LHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAW 405
            :.:::..||....|: |.|..|....:||.|.|.:||||.||.|..::...:.::.||||.||.|
Human   275 NVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPW 339

  Fly   406 PCRLQAEIIIRDQCT--NVADA--EDYVKTIFVRKKSDDFIQSNQYFHIPHKVITS--RNYLRND 464
            |.|.:...::.||..  :..||  .|.....|.|.:|:..:.|......|...:.|  ..|:::|
Human   340 PFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDD 404

  Fly   465 SMFIE 469
            :||::
Human   405 TMFLK 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	SMC_prok_B	<131..>336	CDD:274008	40/228 (18%)
		MATH_TRAF_C	334..473	CDD:238168	44/143 (31%)
TRAF1	NP_005649.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		4/6 (67%)
		TRAF_BIRC3_bd	182..245	CDD:465226	18/108 (17%)
		MATH_TRAF1	267..413	CDD:239748	44/143 (31%)