DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf-like and Rnf41

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001157709.1	Gene:	Rnf41 / 67588	MGIID:	1914838	Length:	317	Species:	Mus musculus

Alignment Length:	334	Identity:	62/334 - (18%)
Similarity:	104/334 - (31%)	Gaps:	152/334 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FCN----EWFDAQ---------TFTEHLIHCGQVLEE--------CPN---GCQAFIPRIRMRSH 83
            |||    :||..|         ....||....:::..        |.|   ||.|.:....:.||
Mouse    38 FCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSH 102

  Fly    84 LKECPRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRK 148
            |.:|   :||                  .:|.:..||..|
Mouse   103 LSDC---EHN------------------PKRPVTCEQGCG------------------------- 121

  Fly   149 QNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKL 213
                                           ..:.:::|....|....:|:.:|.:||:.|.:|
Mouse   122 -------------------------------LEMPKDELPNHNCIKHLRSVVQQQQSRIAELEK- 154

  Fly   214 VNQLSADVTYHQNQL--------------------NDNILKLEELIFENERLNREKFFQIEEFLQ 258
               .||:   |::||                    |.|:..|||.|..||         |.|::.
Mouse   155 ---TSAE---HKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNE---------ILEWVN 204

  Fly   259 QINEDIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERC-----DKLDRALHQTM--QNISDL 316
            .:.....|:.|.  .:::..|.|...:|  :::|   |..|     ::|....|:..  |.::.|
Mouse   205 SLQPARVTRWGG--MISTPDAVLQAVIK--RSLV---ESGCPASIVNELIENAHERSWPQGLATL 262

  Fly   317 ETQMAMQQR 325
            ||:. |.:|
Mouse   263 ETRQ-MNRR 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	10/44 (23%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168
Rnf41	NP_001157709.1	mRING-HC-C3HC3D_Nrdp1	15..57	CDD:319548	6/18 (33%)
		modified RING-HC finger (C3HC3D-type)	18..56	CDD:319548	6/17 (35%)
		USP8_interact	137..315	CDD:370198	37/158 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900