DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and traf5

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_021325328.1	Gene:	traf5 / 563887	ZFINID:	ZDB-GENE-071120-3	Length:	542	Species:	Danio rerio

Alignment Length:	492	Identity:	108/492 - (21%)
Similarity:	186/492 - (37%)	Gaps:	120/492 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SRKDLTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEH-LIHCGQVLEECPNGC 71
            |..|.::....:|..|:|....|     |...:|.:|.:.|.......| ...|..|...|.|.|
Zfish   136 SHSDCSDIVLRKNLLEHQRNACS-----YRLETCHYCRQNFPVSQMMGHQKSSCPDVEVPCSNNC 195

  Fly    72 QAFIPRIRMRSHLKECPRNQHNLSNQQRMSVSMDRLDRQ-----SDQRLLVIEQDVGTIRSVLNE 131
            ...|.|.::::|..||            :.|..|.:.:.     .|:|        |.::...|.
Zfish   196 TQMIKRHQLQAHADEC------------LEVETDCVYKNYGCTVRDKR--------GKVQVHENT 240

  Fly   132 EIRQRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQM---EEETNRKAFAIEQNQLDVQYCC 193
            |....:.|            |:|..|: .||.|:.|::.|   :.....|:..:.....||..|
Zfish   241 EFSAHVRL------------VLESNTK-LEKQMEQLQQDMLVQQGVLKDKSLVVSSLDRDVSLC- 291

  Fly   194 DITQSLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQ 258
                      ::.|...|:.|.:....:...|.:|.|                          |:
Zfish   292 ----------DNTLTTLQRSVEEQRVRICSVQRELRD--------------------------LR 320

  Fly   259 QINEDIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDL-----ET 318
            .:..::|.:|      ...||:||    :::..|..||...:.|. ||.||.:..:.|     |.
Zfish   321 VLGSELKEEL------PRLQASLD----SLRQQVAVTESLREHLG-ALEQTCERHTRLLDIHVEQ 374

  Fly   319 QMAMQQRIASVQ--NIRGHLIWRIKDYSKKLEESKQYDTILHSAMFSNKAFGYALRLDIYLNGKG 381
            ....:||:..::  :..|.|||:::||..:    |:....|.|:.|.....||.|.:..||.|.|
Zfish   375 LQCNEQRLRQLESSSYDGKLIWKVRDYWHR----KESGAALSSSPFYTSRSGYKLSVRAYLGGDG 435

  Fly   382 TWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQC--------TNVADAEDYVKTIFVRKKS 438
            :.:|.:|...:.::.|::|..|.||.|....:.:.||.        |.:.|..   ...|.|..|
Zfish   436 SGRGSHMSLYITIMRGDFDSFLPWPFRQNITLTLLDQSGTRNHMSHTFIPDVN---SDSFHRPTS 497

  Fly   439 DDFIQSNQYFHIPH-KVITSRN--YLRNDSMFIEVRV 472
            |..:.:.....|.| .:...||  ::|::::||:|:|
Zfish   498 DANVATGFTRFISHCDLENPRNAVFVRDETLFIKVKV 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	10/34 (29%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	42/150 (28%)
traf5	XP_021325328.1	RING_Ubox	39..80	CDD:327409
		zf-TRAF	124..179	CDD:280357	10/47 (21%)
		zf-TRAF	179..237	CDD:280357	16/77 (21%)
		SMC_N	<238..>387	CDD:330553	40/209 (19%)
		MATH_TRAF_C	392..535	CDD:238168	42/150 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910