DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Traf-like and traf7

DIOPT Version :9

Sequence 1:NP_727976.1 Gene:Traf-like / 32611 FlyBaseID:FBgn0030748 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_001073654.1 Gene:traf7 / 563746 ZFINID:ZDB-GENE-070112-2212 Length:639 Species:Danio rerio


Alignment Length:415 Identity:87/415 - (20%)
Similarity:144/415 - (34%) Gaps:123/415 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 LFCNEWFDAQTFTEHLIHCGQVLEECPN--GCQAFIPRIRMRSHLKE-----CPRNQHN---LSN 96
            |.|.......|..:|.:.|......|||  .|...: .:.:.:||||     ||.:::.   :.|
Zfish   177 LGCPFTIKLSTRKDHEVSCDYRPVRCPNNPNCPPLL-TMNLEAHLKECEHIKCPHSKYGCTFIGN 240

  Fly    97 QQRMSVSMD--------RLDRQSDQR-------LLVIEQDVGTIRSVLNEEIRQRLHLITDVGNI 146
            |......::        ...:|:|.|       |...:||:..:||:|.                
Zfish   241 QDTYETHLEVCKFEGLKEFLQQTDDRFHEMQVTLAQKDQDISFLRSMLG---------------- 289

  Fly   147 RKQNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQ 211
                       :.:|| :|.|.:.:|                          ||..|   |||.|
Zfish   290 -----------KLSEK-LDQLEKNLE--------------------------LKFDV---LDENQ 313

  Fly   212 KLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSD---- 272
            ..:::...:.....:.|||      ||...|.|||.......:.  |||.:...|.:|:..    
Zfish   314 SKLSEDLMEFRRDASMLND------ELSHINARLNMGILGSYDP--QQIFKCKGTFVGHQGPVWC 370

  Fly   273 ---YVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQ-QRIASVQNIR 333
               |.|..........|::|.....|..:|.|       |::....:...:.:| .::.|.....
Zfish   371 LCVYSTGDLLFSGSSDKSIKVWDTCTTYKCQK-------TLEGHDGIVLALCIQGNKLYSGSADC 428

  Fly   334 GHLIWRIKDYSKKLEESKQYD----TIL--HSAMFSN--KAF------GYALRLDIYLNGKGTWK 384
            ..::|.|:.. :|:...:.:|    |::  |:.:||.  ||.      |..|:|...|.|...|.
Zfish   429 TIIVWDIQTL-QKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWV 492

  Fly   385 GRNMIACLNVL-SGEYDPLLAWPCR 408
             |.::|..|.| ||.|..:..|..|
Zfish   493 -RALVASQNHLYSGSYQTIKIWDIR 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Traf-likeNP_727976.1 zf-TRAF_2 <54..88 CDD:292587 10/40 (25%)
MATH_TRAF_C 334..473 CDD:238168 25/90 (28%)
traf7NP_001073654.1 RING 100..132 CDD:214546
Sina 141..>249 CDD:302762 17/72 (24%)
Snapin_Pallidin 260..342 CDD:291383 28/144 (19%)
WD40 <349..637 CDD:225201 40/179 (22%)
WD40 357..637 CDD:238121 37/169 (22%)
WD40 repeat 368..406 CDD:293791 8/44 (18%)
WD40 repeat 412..446 CDD:293791 5/34 (15%)
WD40 repeat 451..486 CDD:293791 9/34 (26%)
WD40 repeat 493..525 CDD:293791 9/24 (38%)
WD40 repeat 531..565 CDD:293791
WD40 repeat 573..608 CDD:293791
WD40 repeat 615..637 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0297
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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