DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and traf6

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001038217.1	Gene:	traf6 / 554561	ZFINID:	ZDB-GENE-030131-5735	Length:	542	Species:	Danio rerio

Alignment Length:	477	Identity:	100/477 - (20%)
Similarity:	170/477 - (35%)	Gaps:	132/477 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIRMRSHLKECPRNQHNLSNQQRMSV 102
            |.|...|:|..:.:...:||..|......||. ||..:|    .|||.| .::||.|   ||:..
Zfish   134 KCSNFGCSEKMELRQLEKHLSQCRFATAPCPQ-CQESVP----ISHLDE-HKSQHCL---QRIMT 189

  Fly   103 SMDRLD------RQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVV-------E 154
            ..|...      :|:.::.......|.....:  |.||.:|.|..|...::......       |
Zfish   190 CPDCAGSFVYAVKQNHEQFCPFANTVCEYCEM--ELIRDQLALHCDTDCLKAPVACTFSTFGCRE 252

  Fly   155 DWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSA 219
            ..||      ::|.:.|:|.|          |:.::|..:..:|            |.|.|....
Zfish   253 KMTR------NELAQHMQEFT----------QMHMRYMAEFLRS------------QTLNNCTMP 289

  Fly   220 DVTYHQN--------------QLNDNILKLEELIFENE-RLNREKFFQIEEFLQQINEDIKTKLG 269
            ....|.:              |....:|.|.|.:.|.| ||.|:.        |||.|
Zfish   290 SAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQD--------QQIRE------- 339

  Fly   270 NSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASVQNIRG 334
                       |.......||.|.|       |.|.|....::..:||           .|..:|
Zfish   340 -----------LCIHNDTQKNQVTE-------LRRKLVSLEESTRELE-----------AQQYQG 375

  Fly   335 HLIWRIKDYSKKL--EESKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIAC-LNVLS 396
            ..:||::::|..|  :|:.| ..:|||..|.....||.|.|.::|......:..|.|:. ::.:.
Zfish   376 IYVWRVENFSHHLRNQEAGQ-PIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVHTMQ 439

  Fly   397 GEYDPLLAWPCRLQAEIIIRDQCTNVADAEDYVKTIFVRKKSDDF----IQSN-------QYFHI 450
            ||:|..|:||.:....:.:.||    .:.:.:::.:..:.....|    :..|       .:.|:
Zfish   440 GEFDSQLSWPLQGTIRLAVLDQ----VEGQHHIEVMETKPDLQAFQRPTVMRNPKGFGYVTFLHL 500

  Fly   451 PHKVITSRNYLRNDSMFIEVRV 472
              :.:..|.:::.|.:.:...|
Zfish   501 --QALRQRGFVKEDVLLVRCEV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	12/33 (36%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	32/153 (21%)
traf6	NP_001038217.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..54
		RING	71..108	CDD:214546
		zf-TRAF	205..262	CDD:280357	11/64 (17%)
		MATH_TRAF6	375..521	CDD:239745	32/153 (21%)
		Substrate binding. /evidence=ECO:0000250	489..496		0/6 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.770