DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and traf3

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001003513.1	Gene:	traf3 / 445119	ZFINID:	ZDB-GENE-040801-257	Length:	573	Species:	Danio rerio

Alignment Length:	491	Identity:	111/491 - (22%)
Similarity:	202/491 - (41%)	Gaps:	113/491 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKDLTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEHLIH----CGQVLEECPN 69
            |||:.|....:              .|:.:.:|.||:.   ....||...|    |......|||
Zfish   161 RKDMPEHLSRK--------------CKHREVTCEFCSL---KMALTELQKHKETVCPAFPVACPN 208

  Fly    70 GCQ-AFIPRIRMRSHLKECPRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEI 133
            .|. :.|.|..:.||..:||:.|        ::.|..|               .|.....||:|:
Zfish   209 HCSFSSILRSELSSHQHDCPKAQ--------VTCSFIR---------------YGCSYKGLNQEM 250

  Fly   134 RQRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQS 198
            |:                      .|:..|.:.||          ..|:....|:.:.
Zfish   251 RE----------------------HESSFASEHLR----------MMAVRNTTLEAKV------- 276

  Fly   199 LKEQVESRLDEAQKLVNQLS---ADVTYHQNQLNDNILKLEELIFENERL---NREKFFQIEEFL 257
              |.|:|.|.|..|::..||   |:|.....::.:...:||:.:...:.|   :.||..::|..|
Zfish   277 --EDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNRQLEQKLVSMQMLMSSHSEKLLEVEMEL 339

  Fly   258 QQI------NEDIKTKLGNSDYVTSKQATLDYEVKNV---KNIVCETEERCDKLDRALHQTMQNI 313
            :::      .|:::|..|:.:.:.|..::||....|.   .:.:...|::..:     |..:.::
Zfish   340 RELRPLRAMREEVETLRGSVESMRSMVSSLDSSCVNSASGSHTLASLEQQLTR-----HDDLMSV 399

  Fly   314 SDLE-TQMAMQQRIASVQNIRGHLIWRIKDYSKKLEESKQYDTI-LHSAMFSNKAFGYALRLDIY 376
            .|:. .:|.::.::....:..|.|||:|:||.::.:|:....|: |:|..|....|||.:...:|
Zfish   400 HDVRLAEMDLKLQVLETASFNGTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVY 464

  Fly   377 LNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQ---CTNVADA--EDYVKTIFVRK 436
            |||.|..||.::.....|:.||||.||.||.:.:..:::.||   ..::.||  .|...:.|.|.
Zfish   465 LNGDGMGKGTHLSLFFVVMRGEYDALLQWPFKQKVTLMLMDQGPARKHLGDAFKPDPSSSSFRRP 529

  Fly   437 KSDDFIQSNQYFHIPHKVITSRNYLRNDSMFIEVRV 472
            ..:..|.|.....:...|:.:..|:::|::||:|.|
Zfish   530 TGEMNIASGCPLFVAQTVLENGTYIKDDTIFIKVTV 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	12/38 (32%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	47/145 (32%)
traf3	NP_001003513.1	RING	55..92	CDD:214546
		zf-TRAF	139..194	CDD:280357	10/49 (20%)
		zf-TRAF	198..253	CDD:280357	19/99 (19%)
		Prefoldin	<249..322	CDD:298833	20/113 (18%)
		MATH_TRAF3	383..568	CDD:239746	51/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7181
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010