DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and Traf6

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001101224.1	Gene:	Traf6 / 311245	RGDID:	1306853	Length:	530	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	101/483 - (20%)
Similarity:	178/483 - (36%)	Gaps:	114/483 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIR 79
            :||....|..:.:..|.| ||.....|:   :..:.:...:|.:||...|..||. ||.|..:.:
  Rat   114 ENQLFPDNFAKREILSLT-VKCPNKGCV---QKMELRHLEDHQVHCEFALVICPQ-CQRFFQKCQ 173

  Fly    80 MRSH-LKECPRNQHNLSN-QQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITD 142
            :..| :::|||.|.:..| ...|......:..||.....:|.:..|||  ::.|::.....|...
  Rat   174 INKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTI--LIREQMPNHYDLDCP 236

  Fly   143 VGNIRKQNQVV---EDWTRETEKAMDDLRRQMEEETNRK----AFAIEQNQLDVQYCCDITQSLK 200
            ...:.....|.   |...|      :.|.|.::|.|...    |.|:....|.::.|
  Rat   237 TAPVPCTFSVFGCHEKMQR------NHLARHLQENTQLHMRLLAQAVHNVNLSLRPC-------- 287

  Fly   201 EQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENE-RLNREKFFQIEEFLQQINEDI 264
                   |.:.........|..|            ||.:.:.| ||.|:.        .||.|
  Rat   288 -------DASSPSRGCRPEDPNY------------EETVKQLEGRLVRQD--------HQIRE-- 323

  Fly   265 KTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASV 329
                     :|:|..|....|..:|                  :|::::.|...:|..||
  Rat   324 ---------LTAKMETQSMHVSELK------------------RTIRSLEDKVAEMEAQQ----- 356

  Fly   330 QNIRGHLIWRIKDYSKKLE-ESKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIAC-L 392
              ..|..||:|.::...|: :.::...::||..|.....||.|.:.::|......:..|.|:. :
  Rat   357 --CNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV 419

  Fly   393 NVLSGEYDPLLAWP----CRL----QAEIIIRDQCTNVADAEDYV-----KTIFVRKKSDDFIQS 444
            :.:.||||..|.||    .||    |:|.:||.....|.||:..:     .||....|...::
  Rat   420 HTMQGEYDSHLPWPFQGTIRLTILDQSEAVIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYV-- 482

  Fly   445 NQYFHIPHKVITSRNYLRNDSMFIEVRV 472
             .:.|:  :.:....::::|::.:...|
  Rat   483 -TFMHL--EALRQGTFIKDDTLLVRCEV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	10/34 (29%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	36/154 (23%)
Traf6	NP_001101224.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		66/331 (20%)
		mRING-HC-C3HC3D_TRAF6	67..124	CDD:319557	3/9 (33%)
		PLN03086	<132..219	CDD:178635	22/90 (24%)
		TRAF6_Z2	157..183	CDD:407885	7/26 (27%)
		zf-TRAF	204..261	CDD:280357	12/64 (19%)
		DUF460	<273..>352	CDD:421465	23/142 (16%)
		MATH_TRAF6	359..508	CDD:239745	36/154 (23%)
		Interaction with TANK. /evidence=ECO:0000250\|UniProtKB:Q9Y4K3	363..530		34/150 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770