DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and Traf7

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001165584.1	Gene:	Traf7 / 224619	MGIID:	3042141	Length:	669	Species:	Mus musculus

Alignment Length:	403	Identity:	84/403 - (20%)
Similarity:	145/403 - (35%)	Gaps:	125/403 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EHLIHCGQVLEECPN--GCQAFIPRIRMRSHLKE-----CPRNQHN---LSNQQRMSVSMD--RL 107
            :|...|......|||  .|...: ::.:.:||||     ||.:::.   :.||......::  |.
Mouse   220 DHESSCDYRPVRCPNNPSCPPLL-KMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRF 283

  Fly   108 D------RQSDQR-------LLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRE 159
            :      :|:|.|       |...:|::..:||:|.                           :.
Mouse   284 EGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLG---------------------------KL 321

  Fly   160 TEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADVTYH 224
            :|| :|.|.:.:|                          ||..|   |||.|..:::...:....
Mouse   322 SEK-IDQLEKSLE--------------------------LKFDV---LDENQSKLSEDLMEFRRD 356

  Fly   225 QNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYV----TSKQATLDYEV 285
            .:.|||      ||...|.|||.......:.  |||.:...|.:|:...|    ......|.:..
Mouse   357 ASMLND------ELSHINARLNMGILGSYDP--QQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSG 413

  Fly   286 KNVKNI----VCETEERCDKLDRALHQTMQNISDLETQMAMQQ-RIASVQNIRGHLIWRIKDYSK 345
            .:.|.|    .| |..:|.|       |::....:...:.:|. ::.|.......::|.|::. :
Mouse   414 SSDKTIKVWDTC-TTYKCQK-------TLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNL-Q 469

  Fly   346 KLEESKQYD----TIL--HSAMFSN--KAF------GYALRLDIYLNGKGTWKGRNMIACLNVL- 395
            |:...:.:|    |::  |:.:||.  ||.      |..|:|...|.|...|. |.::|..:.|
Mouse   470 KVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWV-RALVAAQSYLY 533

  Fly   396 SGEYDPLLAWPCR 408
            ||.|..:..|..|
Mouse   534 SGSYQTIKIWDIR 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	10/39 (26%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	24/90 (27%)
Traf7	NP_001165584.1	RING	130..162	CDD:214546
		Sina	206..>279	CDD:302762	14/59 (24%)
		DD_cGKI	281..321	CDD:213458	9/66 (14%)
		WD40	<379..667	CDD:225201	40/180 (22%)
		WD40	387..667	CDD:238121	37/170 (22%)
		WD40 repeat	442..476	CDD:293791	5/34 (15%)
		WD40 repeat	481..516	CDD:293791	9/34 (26%)
		WD40 repeat	526..555	CDD:293791	7/21 (33%)
		WD40 repeat	561..595	CDD:293791
		WD40 repeat	603..638	CDD:293791
		WD40 repeat	645..667	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810