DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and Traf6

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001290202.1	Gene:	Traf6 / 22034	MGIID:	108072	Length:	530	Species:	Mus musculus

Alignment Length:	485	Identity:	105/485 - (21%)
Similarity:	180/485 - (37%)	Gaps:	118/485 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIR 79
            :||....|..:.:..|.| ||.....||   :..:.:...:|.:||...|..||. ||....:.:
Mouse   114 ENQLFPDNFAKREILSLT-VKCPNKGCL---QKMELRHLEDHQVHCEFALVNCPQ-CQRPFQKCQ 173

  Fly    80 MRSH-LKECPRNQHNLSNQQRMSVSM----DRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHL 139
            :.:| :::|||.|.:..|   .:|||    ..:..||.....:|.:..|||  ::.|::.....|
Mouse   174 VNTHIIEDCPRRQVSCVN---CAVSMAYEEKEIHDQSCPLANIICEYCGTI--LIREQMPNHYDL 233

  Fly   140 ITDVGNIRKQNQVV---EDWTRETEKAMDDLRRQMEEETNRK----AFAIEQNQLDVQYCCDITQ 197
            ......|.....|.   |...|      :.|.|.::|.|...    |.|:....|.::.|
Mouse   234 DCPTAPIPCTFSVFGCHEKMQR------NHLARHLQENTQLHMRLLAQAVHNVNLALRPC----- 287

  Fly   198 SLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINE 262
                      |.|.........|..|     .:.|.:||      .||.|:.        .||.|
Mouse   288 ----------DAASPSRGCRPEDPNY-----EETIKQLE------SRLVRQD--------HQIRE 323

  Fly   263 DIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIA 327
                       :|:|..|....|..:|                  :|::.:.|...:|..||
Mouse   324 -----------LTAKMETQSMYVGELK------------------RTIRTLEDKVAEMEAQQ--- 356

  Fly   328 SVQNIRGHLIWRIKDYSKKLE-ESKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIAC 391
                ..|..||:|.::...|: :.::...::||..|.....||.|.:.::|......:..|.|:.
Mouse   357 ----CNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISL 417

  Fly   392 -LNVLSGEYDPLLAWP----CRL----QAEIIIRDQCTNVADAEDYV-----KTIFVRKKSDDFI 442
             ::.:.||||..|.||    .||    |:|.:||.....|.||:..:     .||....|...::
Mouse   418 FVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYV 482

  Fly   443 QSNQYFHIPHKVITSRNYLRNDSMFIEVRV 472
               .:.|:  :.:....::::|::.:...|
Mouse   483 ---TFMHL--EALRQGTFIKDDTLLVRCEV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	9/34 (26%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	36/154 (23%)
Traf6	NP_001290202.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		70/333 (21%)
		RING	69..107	CDD:238093
		zf-TRAF	204..261	CDD:280357	13/64 (20%)
		SlyX	304..>356	CDD:294687	17/94 (18%)
		MATH_TRAF6	359..508	CDD:239745	36/154 (23%)
		Interaction with TANK. /evidence=ECO:0000250\|UniProtKB:Q9Y4K3	363..530		34/150 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770