Protein Alignment Traf-like and Traf6

DIOPT Version :10

• Sequence 1: NP_727976.1
• Gene: Traf-like / 32611
• FlyBaseID: FBgn0030748
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_033450.2
• Gene: Traf6 / 22034
• MGIID: 108072
• Length: 530
• Species: Mus musculus
• Alignment Length: 485
• Identity: 105/485 - (21%)
• Similarity: 180/485 - (37%)
• Gaps: 118/485 - (24%)

  Fly    15 QNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIR 79
            :||....|..:.:..|.| ||.....||   :..:.:...:|.:||...|..||. ||....:.:
Mouse   114 ENQLFPDNFAKREILSLT-VKCPNKGCL---QKMELRHLEDHQVHCEFALVNCPQ-CQRPFQKCQ 173

  Fly    80 MRSH-LKECPRNQHNLSNQQRMSVSM----DRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHL 139
            :.:| :::|||.|.:..|   .:|||    ..:..||.....:|.:..|||  ::.|::.....|
Mouse   174 VNTHIIEDCPRRQVSCVN---CAVSMAYEEKEIHDQSCPLANIICEYCGTI--LIREQMPNHYDL 233

  Fly   140 ITDVGNIRKQNQVV---EDWTRETEKAMDDLRRQMEEETNRK----AFAIEQNQLDVQYCCDITQ 197
            ......|.....|.   |...|      :.|.|.::|.|...    |.|:....|.::.|
Mouse   234 DCPTAPIPCTFSVFGCHEKMQR------NHLARHLQENTQLHMRLLAQAVHNVNLALRPC----- 287

  Fly   198 SLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINE 262
                      |.|.........|..|     .:.|.:||      .||.|:.        .||.|
Mouse   288 ----------DAASPSRGCRPEDPNY-----EETIKQLE------SRLVRQD--------HQIRE 323

  Fly   263 DIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIA 327
                       :|:|..|....|..:|                  :|::.:.|...:|..||
Mouse   324 -----------LTAKMETQSMYVGELK------------------RTIRTLEDKVAEMEAQQ--- 356

  Fly   328 SVQNIRGHLIWRIKDYSKKLE-ESKQYDTILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIAC 391
                ..|..||:|.::...|: :.::...::||..|.....||.|.:.::|......:..|.|:.
Mouse   357 ----CNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISL 417

  Fly   392 -LNVLSGEYDPLLAWP----CRL----QAEIIIRDQCTNVADAEDYV-----KTIFVRKKSDDFI 442
             ::.:.||||..|.||    .||    |:|.:||.....|.||:..:     .||....|...::
Mouse   418 FVHTMQGEYDSHLPWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYV 482

  Fly   443 QSNQYFHIPHKVITSRNYLRNDSMFIEVRV 472
               .:.|:  :.:....::::|::.:...|
Mouse   483 ---TFMHL--EALRQGTFIKDDTLLVRCEV 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	SMC_prok_B	<131..>336	CDD:274008	38/211 (18%)
		MATH_TRAF_C	334..473	CDD:238168	36/154 (23%)
Traf6	NP_033450.2	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		70/333 (21%)
		mRING-HC-C3HC3D_TRAF6	67..124	CDD:438305	3/9 (33%)
		TRAF6_Z2	157..183	CDD:436235	6/26 (23%)
		zf-TRAF	204..261	CDD:280357	13/64 (20%)
		MATH_TRAF6	359..508	CDD:239745	36/154 (23%)
		Interaction with TANK. /evidence=ECO:0000250|UniProtKB:Q9Y4K3	363..530		34/150 (23%)