Protein Alignment Traf-like and Traf5

DIOPT Version :9

• Sequence 1: NP_727976.1
• Gene: Traf-like / 32611
• FlyBaseID: FBgn0030748
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_035763.2
• Gene: Traf5 / 22033
• MGIID: 107548
• Length: 558
• Species: Mus musculus
• Alignment Length: 534
• Identity: 118/534 - (22%)
• Similarity: 187/534 - (35%)
• Gaps: 189/534 - (35%)

  Fly     2 SLTKSSSRKDLTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFTEHLIH-CGQVLE 65
            |..::..|||:.|.              .:...::.:..||:|..........:|..: |.....
Mouse   143 SCREAMLRKDVKEH--------------LSAYCRFREEKCLYCKRDIVVTNLQDHEENSCPAYPV 193

  Fly    66 ECPNGCQAFIPRIRMRSHLKECPRNQH----------------NLSNQQRMSVSMDRLDRQSDQR 114
            .|||.|...|||.|:..||..||..:.                ||...:|.::        .|..
Mouse   194 SCPNRCVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTVKGKRGNLLEHERAAL--------QDHM 250

  Fly   115 LLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEETNRKA 179
            |||:|:         |.::.||:
Mouse   251 LLVLEK---------NYQLEQRI------------------------------------------ 264

  Fly   180 FAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELIFENER 244
                         .|:.||| ||.||::                  .||.:.:.|.|:
Mouse   265 -------------SDLYQSL-EQKESKI------------------QQLAETVKKFEK------- 290

  Fly   245 LNREKFFQIEEFLQQINEDIKTKLGNSDYVTS---KQATLDYEVKNVKNIVCETEERCD--KLDR 304
                   ::::|.|....: .|.|.|...:||   |.|.|:.:|:.:..||.:...|.|  .|..
Mouse   291 -------ELKQFTQMFGRN-GTFLSNVQALTSHTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVD 347

  Fly   305 ALHQTMQNISDLETQMAMQQRIASVQ----------NIR--------------------GHLIWR 339
            |:....|.|:.||   |..||:..::          ||.                    |.|||:
Mouse   348 AVDSVKQRITQLE---ASDQRLVLLEGETSKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWK 409

  Fly   340 IKDYSKKLEESKQYDTI-LHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLL 403
            :.||..|..|:.:..|: :.|..|.....||.|....||||.|:.||.::.....|:.||:|.||
Mouse   410 VTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLL 474

  Fly   404 AWPCRLQAEIIIRDQC--------TNVADAEDYVKTIFVRKKSDDFIQSNQYFHIPHKVI-TSRN 459
            .||.|.:..:::.||.        |..||..   .:.|.|...:..|.|.....:.|..: .|:|
Mouse   475 QWPFRQRVTLMLLDQSGKKNHIVETFKADPN---SSSFKRPDGEMNIASGCPRFVSHSTLENSKN 536

  Fly   460 -YLRNDSMFIEVRV 472
             |:::|::|::|.|
Mouse   537 TYIKDDTLFLKVAV 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	12/34 (35%)
		MATH_TRAF_C	334..473	CDD:238168	47/150 (31%)
Traf5	NP_035763.2	mRING-HC-C3HC3D_TRAF5	43..85	CDD:319556
		zf-TRAF	128..183	CDD:280357	8/53 (15%)
		zf-TRAF	185..241	CDD:424248	15/55 (27%)
		Smc	<237..>419	CDD:224117	56/290 (19%)
		Interaction with EIF2AK2/PKR. /evidence=ECO:0000250	345..558		58/212 (27%)
		MATH_TRAF5	404..551	CDD:239749	47/150 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010